Learning from PD-1 Resistance: New Combination Strategies

被引：55

作者：

Bu, Xia ^{[1
]}

Mahoney, Kathleen M. ^{[1
,2
]}

Freeman, Gordon J. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, 44 Binney St, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol, 44 Binney St, Boston, MA 02115 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2016年 / 22卷 / 06期

关键词：

IMMUNE CHECKPOINTS; MELANOMA; BLOCKADE; CELL;

D O I：

10.1016/j.molmed.2016.04.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Only a minority of cancer patients respond to anti PD-1 immunotherapy. A recent study demonstrates that PD-1 therapy-resistant melanoma patients present distinct signatures of upregulated genes involved in immunosuppression, angiogenesis, monocyte and macrophage chemotaxis, extracellular matrix remodeling, and epithelial-mesenchymal transition (EMT). Combination targeting of these pathways with PD-1 may help overcome PD-1 resistance, thus producing effective antitumor immunity.

引用

页码：448 / 451

页数：4

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