Protein-Resistant Materials via Surface-Initiated Atom Transfer Radical Polymerization of 2-Methacryloyloxyethyl Phosphorylcholine

被引：19

作者：

Jin, Zhilin

Feng, Wei

Zhu, Shiping

Sheardown, Heather

Brash, John L. ^{[1
]}

机构：

[1] McMaster Univ, Dept Chem Engn, Hamilton, ON L8S 4L7, Canada

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2010年 / 21卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Surface modification; atom transfer radical polymerization (ATRP); protein-resistant surface; phosphorylcholine; MPC; HEPARIN-IMMOBILIZED POLYURETHANES; OXYGEN PLASMA-TREATMENT; PHOSPHOLIPID POLYMERS; SILICONE-RUBBER; CHAIN DENSITY; ADSORPTION; POLY(DIMETHYLSILOXANE); FIBRINOGEN; COPOLYMER; PERMANENT;

D O I：

10.1163/092050609X12517190417713

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Poly(2-methacryloyloxyethyl phosphorylcholine) (poly(MPC)) was grafted from various polymeric substrates to prepare protein-resistant materials. The poly(MPC) chain length was adjusted via the ratio of monomer to sacrificial initiator in solution. The surfaces were characterized by water contact angle and X-ray photoelectron spectroscopy (XPS). The protein-resistant properties of the poly(MPC)-grafted surfaces were evaluated by single adsorption experiments with fibrinogen and lysozyme. It was shown that the simple three-step grafting method could be applied to modify various biomaterial surfaces including polyurethane and silicones. The adsorption of fibrinogen and lysozyme to the modified surfaces was greatly reduced compared to the unmodified surfaces, and adsorption decreased with increasing poly(MPC) chain length. On polyurethane film grafted with poly(MPC) of chain length 100, the reduction in adsorption was approx. 96% for lysozyme and approx. 99% for fibrinogen. (C) Koninklijke Brill NV, Leiden, 2010

引用

页码：1331 / 1344

页数：14

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