Lifetime manic-hypomanic symptoms in post-traumatic stress disorder: Relationship with the 18 kDa mitochondrial translocator protein density

被引:33
作者
Dell'Osso, Liliana [1 ]
Da Pozzo, Eleonora [1 ]
Carmassi, Claudia [1 ]
Trincavelli, Maria Letizia [1 ]
Ciapparelli, Antonio [1 ]
Martini, Claudia [1 ]
机构
[1] Univ Pisa, Dept Psychiat Neurobiol Pharmacol & Biotechnol, I-56126 Pisa, Italy
关键词
Post-traumatic stress disorder (PTSD); Mitochondrial translocator protein (18 kDa)(TSPO); Mood spectrum; Trauma; PERIPHERAL BENZODIAZEPINE-RECEPTOR; BIPOLAR DISORDER; MOOD SPECTRUM; AXIS FUNCTION; COMORBIDITY; STEROIDOGENESIS; LYMPHOCYTES; CORTISOL; TRAUMA;
D O I
10.1016/j.psychres.2008.07.019
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Initially explored in military settings, post-traumatic stress disorder (PTSD) has shown increasing prevalence in the general population. The high comorbidity rates between bipolar disorder (BD) and PTSD have raised the issue of whether some characteristics of BD could represent risk factors for PTSD. In combat-related PTSD, the 18 kDa mitochondrial translocator protein (TSPO), essential for steroid synthesis, was found to be decreased. Aims of the present study were: 1) the assessment of the TSPO mitochondrial density in lymphomonocytes from civilian patients with non-combat-related PTSD, without current or lifetime Axis I mood comorbidity, versus controls; 2) the exploration of the correlations between TSPO density and the presence of comorbid manic/hypomanic lifetime spectrum symptoms. Assessments included the Structured Clinical Interview for DSM-IV (SCID), the Impact of Event Scale (IES), and the lifetime Mood Spectrum Self-Report (MOODS-SR). Blood samples were processed to assess TSPO binding parameters in lymphomonocyte mitochondrial membranes. PTSD patients showed a significant decrease in TSPO density, without changes in mitochondrial citrate synthase activity. Further, TSPO density correlated with the number of lifetime manic/hypomanic spectrum symptoms. For the first time, TSPO density was found to be decreased in non-war-related PTSD and such decreases correlated with comorbid manic/hypomanic spectrum symptoms, indicating a possible role of sub-threshold bipolar comorbidity in PTSD-related neurobiological dysregulation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:139 / 143
页数:5
相关论文
共 40 条
[1]   The mood spectrum in unipolar and bipolar disorder: Arguments for a unitary approach [J].
Cassano, GB ;
Rucci, P ;
Frank, E ;
Fagiolini, A ;
Dell'Osso, L ;
Shear, MK ;
Kupfer, DJ .
AMERICAN JOURNAL OF PSYCHIATRY, 2004, 161 (07) :1264-1269
[2]   Peripheral benzodiazepine receptor: Characterization in human T-lymphoma Jurkat cells [J].
Costa, B ;
Salvetti, A ;
Rossi, L ;
Spinetti, F ;
Lena, A ;
Chelli, B ;
Rechichi, M ;
Da Pozzo, E ;
Gremigni, V ;
Martini, C .
MOLECULAR PHARMACOLOGY, 2006, 69 (01) :37-44
[3]   In vitro studies on the role of the peripheral-type benzodiazepine receptor in steroidogenesis [J].
Culty, M ;
Li, H ;
Boujrad, N ;
Amri, H ;
Vidic, B ;
Bernassau, JM ;
Reversat, JL ;
Papadopoulos, V .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1999, 69 (1-6) :123-130
[4]   PLATELET PERIPHERAL BENZODIAZEPINE RECEPTORS IN REPEATED STRESS [J].
DAR, DE ;
WEIZMAN, A ;
KARP, L ;
GRINSHPOON, A ;
BIDDER, M ;
KOTLER, M ;
TYANO, S ;
BLEICH, A ;
GAVISH, M .
LIFE SCIENCES, 1991, 48 (04) :341-346
[5]  
DARVESBORNOZ JM, 1995, ANN MED-PSYCHOL, V153, P286
[6]   Assessment of HPA-axis function in posttraumatic stress disorder: Pharmacological and non-pharmacological challenge tests, a review [J].
de Kloet, C. S. ;
Vermetten, E. ;
Geuze, E. ;
Kavelaars, A. ;
Heijnen, C. J. ;
Westenberg, H. G. M. .
JOURNAL OF PSYCHIATRIC RESEARCH, 2006, 40 (06) :550-567
[7]   Measuring mood spectrum: Comparison of interview (SCI-MOODS) and self-report (MOODS-SR) instruments [J].
Dell'Osso, L ;
Armani, A ;
Rucci, P ;
Frank, E ;
Fagiolini, A ;
Corretti, G ;
Shear, MK ;
Grochocinski, VJ ;
Maser, JD ;
Endicott, J ;
Cassano, GB .
COMPREHENSIVE PSYCHIATRY, 2002, 43 (01) :69-73
[8]  
Dell'osso Liliana, 2008, Clin Pract Epidemiol Ment Health, V4, P2, DOI 10.1186/1745-0179-4-2
[9]   Peripheral benzodiazepine receptors: Molecular pharmacology to possible physiological significance in stress-induced hypertension [J].
Drugan, RC .
CLINICAL NEUROPHARMACOLOGY, 1996, 19 (06) :475-496
[10]   ETIOLOGY OF THE SEXUAL DIMORPHISM IN RENAL PERIPHERAL BENZODIAZEPINE RECEPTOR RESPONSE TO STRESS IN RATS [J].
DRUGAN, RC ;
PARK, R ;
KAUFMAN, L ;
HOLMES, PV .
HORMONES AND BEHAVIOR, 1993, 27 (03) :348-365