The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss

被引：73
作者：
Wolff, Amy. R. [1 ]
Bilkey, David. K. [1 ]
机构：
[1] Univ Otago, Dept Psychol, Dunedin, New Zealand
来源：
BEHAVIOURAL BRAIN RESEARCH | 2010年 / 213卷 / 02期
关键词：
Schizophrenia; Poly I:C; Pre-pulse inhibition; MIA; Juvenile; Sensorimotor-gating; Maternal weight; SCHIZOTYPAL PERSONALITY-DISORDER; ACOUSTIC STARTLE RESPONSE; PREPULSE INHIBITION; PRENATAL EXPOSURE; BRAIN-DEVELOPMENT; DOPAMINERGIC HYPERFUNCTION; PHARMACOLOGICAL CHANGES; SEX-DIFFERENCES; SENSORIMOTOR; INFLUENZA;
D O I：
10.1016/j.bbr.2010.05.008
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The developmental onset of deficits in sensorimotor-gating was examined in the maternal immune activation (MIA) animal model of schizophrenia. Pre-pulse inhibition (PPI) deficits were evident in juvenile MIA rats. This parallels the sensorimotor-gating deficits observed in groups at high-risk of schizophrenia. PPI deficits were independent of maternal weight loss following the MIA manipulation, suggesting that this measure may not be a useful marker of treatment efficacy. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：323 / 327
页数：5
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