Curcumin and Cancer

被引：766

作者：

Giordano, Antonio ^{[1
,2
]}

Tommonaro, Giuseppina ^{[3
]}

机构：

[1] Temple Univ, Sbarro Inst Canc Res & Mol Med, BioLife Sci Bldg,Suite 431-1900 N 12th St, Philadelphia, PA 19122 USA

[2] Temple Univ, Ctr Biotechnol, Coll Sci & Technol, BioLife Sci Bldg,Suite 431-1900 N 12th St, Philadelphia, PA 19122 USA

[3] Natl Res Council Italy, Inst Biomol Chem, Via Campi Flegrei 34, I-80078 Pozzuoli, Italy

来源：

NUTRIENTS | 2019年 / 11卷 / 10期

关键词：

curcumin; cancer; cell signaling pathways; Curcuma longa; NF-KAPPA-B; CELL-CYCLE ARREST; WT1; GENE-EXPRESSION; GROWTH IN-VITRO; DOWN-REGULATION; SUPPRESSES PROLIFERATION; SIGNALING PATHWAY; INHIBITS PROLIFERATION; ANTITUMOR-ACTIVITY; MOLECULAR TARGETS;

D O I：

10.3390/nu11102376

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Curcumin, a polyphenol extracted from Curcuma longa in 1815, has gained attention from scientists worldwide for its biological activities (e.g., antioxidant, anti-inflammatory, antimicrobial, antiviral), among which its anticancer potential has been the most described and still remains under investigation. The present review focuses on the cell signaling pathways involved in cancer development and proliferation, and which are targeted by curcumin. Curcumin has been reported to modulate growth factors, enzymes, transcription factors, kinase, inflammatory cytokines, and proapoptotic (by upregulation) and antiapoptotic (by downregulation) proteins. This polyphenol compound, alone or combined with other agents, could represent an effective drug for cancer therapy.

引用

页数：20

共 136 条

[131] Computational analyses of curcuminoid analogs against kinase domain of HER2 [J].