Epigenetics of kidney disease

被引：50

作者：

Wanner, Nicola ^{[1
,3
]}

Bechtel-Walz, Wibke ^{[1
,2
,3
]}

机构：

[1] Univ Freiburg, Fac Med, Dept Med 4, Freiburg, Germany

[2] Albert Ludwigs Univ, Ctr Syst Biol ZBSA, Freiburg, Germany

[3] Univ Hosp Freiburg, Renal Div, Breisacher Str 66, D-79106 Freiburg, Germany

来源：

CELL AND TISSUE RESEARCH | 2017年 / 369卷 / 01期

关键词：

Epigenetics; Kidney; Chronic kidney disease; Diabetes; Epigenetic therapy; TO-MESENCHYMAL TRANSITION; HYPOXIA-INDUCIBLE FACTOR; PROMOTES RENAL FIBROSIS; ANGIOTENSIN-CONVERTING ENZYME; DIABETIC-NEPHROPATHY; DNA METHYLATION; HISTONE ACETYLATION; DE-NOVO; GENE-EXPRESSION; MOUSE MODEL;

D O I：

10.1007/s00441-017-2588-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA methylation and histone modifications determine renal programming and the development and progression of renal disease. The identification of the way in which the renal cell epigenome is altered by environmental modifiers driving the onset and progression of renal diseases has extended our understanding of the pathophysiology of kidney disease progression. In this review, we focus on current knowledge concerning the implications of epigenetic modifications during renal disease from early development to chronic kidney disease progression including renal fibrosis, diabetic nephropathy and the translational potential of identifying new biomarkers and treatments for the prevention and therapy of chronic kidney disease and end-stage kidney disease.

引用

页码：75 / 92

页数：18