Temperature-dependent optical properties of Intralipid® measured with frequency-domain photon-migration spectroscopy

We present the temperature dependence of absorption and reduced scattering coefficients of 1.8% Intralipid measured by frequency-domain photon-migration spectroscopy between 710 and 850 nm. These measurements were made in the physiologically relevant 30 to 40 degrees C temperature range. The temperature coefficients for absorption were consistent during heating and cooling and follow closely other reported results. The change in absorption coefficient at 740 nm suggests that a minimum temperature change of 4 degrees C is observable within the error limits. We found that the reduced scattering coefficient shows a hysteresis with temperature at 740 nm. The temperature coefficient for reduced scattering determined from heating cycle measurements agrees with theory and other measurements within the error limits. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3290820]