Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

被引：426

作者：

Rey, Sergio ^{[1
,2
]}

Semenza, Gregg L. ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Vasc Program, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Pediat, Sch Med, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Dept Oncol, Sch Med, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Dept Radiat Oncol, Sch Med, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Dept Biol Chem, Sch Med, Baltimore, MD 21205 USA

来源：

CARDIOVASCULAR RESEARCH | 2010年 / 86卷 / 02期

关键词：

Angiogenesis; Cell therapy; Gene therapy; HIF-1; Hypoxia; Vascularization; ENDOTHELIAL GROWTH-FACTOR; CRITICAL LIMB ISCHEMIA; COLLATERAL ARTERY FORMATION; AGE-DEPENDENT IMPAIRMENT; FACTOR-I; GENE-EXPRESSION; TRANSCRIPTIONAL ACTIVITY; PULMONARY VASOCONSTRICTION; RETINAL NEOVASCULARIZATION; HIF-1-ALPHA SYNTHESIS;

D O I：

10.1093/cvr/cvq045

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models.

引用

页码：236 / 242

页数：7

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