A short-step synthesis of (2S,3R)-3-hydroxy-3-methylproline, a component of polyoxypeptins, using a tandem Michael-Aldol reaction and optical resolution

被引：8
作者：
Makino, K [1 ]
Suzuki, T [1 ]
Hamada, Y [1 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan
来源：
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2004年 / 77卷 / 09期
关键词：
D O I：
10.1246/bcsj.77.1649
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A short-step synthesis of (2S,3R)-3-hydroxy-3-inethylproline, a component of polyoxypeptins, using a tandem Michael-aldol reaction followed by its optical resolution using (-)-cinchonidine has been achieved.
引用
收藏
页码：1649 / 1653
页数：5
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