Self-assembled multifunctional Fe/MgO nanospheres for magnetic resonance imaging and hyperthermia

被引：89

作者：

Martinez-Boubeta, Carlos ^{[1
,2
]}

Balcells, Lluis ^{[2
]}

Cristofol, Rosa ^{[3
]}

Sanfeliu, Coral ^{[3
]}

Rodriguez, Elisenda ^{[4
]}

Weissleder, Ralph ^{[4
]}

Lope-Piedrafita, Silvia ^{[5
]}

Simeonidis, Konstantinos ^{[6
]}

Angelakeris, Makis ^{[6
]}

Sandiumenge, Felip ^{[2
]}

Calleja, Alberto ^{[2
,7
]}

Casas, Lluis ^{[8
]}

Monty, Claude ^{[9
]}

Martinez, Benjamin ^{[2
]}

机构：

[1] Univ Barcelona, Dept Elect, IN2UB, E-08028 Barcelona, Spain

[2] ICMAB CSIC, Bellaterra, Spain

[3] CSIC IDIBAPS, IIBB, Barcelona, Spain

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Mol Imaging Res, Boston, MA USA

[5] Univ Autonoma Barcelona, Serv Resonancia Magnet Nucl, Bellaterra, Spain

[6] Aristotle Univ Thessaloniki, Dept Phys, GR-54006 Thessaloniki, Greece

[7] UAB, Inst Ciencia & Tecnol Ambientals, Bellaterra, Spain

[8] UAB, Unitat Cristal Log & Mineral, Dept Geol, Bellaterra, Spain

[9] CNRS Procedes Mat & Energie Solaire, Font Romeu, France

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2010年 / 6卷 / 02期

关键词：

Core-shell; Hyperthermia; Magnetism; MRI; Nanoparticles; Vapor condensation; NANOPARTICLES; MORPHOLOGY; PARTICLES; EXCRETION; SYSTEM; TISSUE; MGO;

D O I：

10.1016/j.nano.2009.09.003

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A one-step process for the production of nanoparticles presenting advanced magnetic properties can be achieved using vapor condensation. In this article, we report on the fabrication of Fe particles covered by a uniform MgO epitaxial shell. MgO has a lower surface energy than Fe, which results in a core-shell crystal formation. The particles satisfy a few of technical requirements for the practical use in real clinics, such as a high biocompatibility in living cells in-vitro, an injection through blood vessels without any clothing problems in murine model, a high absorption rate for magnetic hyperthermia at small particle concentration, and the potential to be used as contrast agent in the field of diagnostic magnetic imaging. They are also able to be used in drug delivery and magnetic-activated cell sorting. From the Clinical Editor: In this paper, the authors report on the synthesis of Fe particles covered by a uniform MgO epitaxial shell resulting in a core-shell crystal formation. The particles are proven to be useful as contrast agents for magnetic resonance imaging and have the potential to be useful as heating mediators for cancer therapy through hyperthermia. They also might be used in drug delivery and magnetic-activated cell sorting. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：362 / 370

页数：9

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