Copper-Catalyzed Intramolecular Amination of C(sp3)-H Bond of Secondary Amines to Access Azacycles

被引：18
|
作者：
Jin, Ruo-Xing [1 ,2 ]
Dai, Jing-Cheng [1 ,2 ]
Li, Yan [1 ,2 ]
Wang, Xi-Sheng [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 02期
基金：
美国国家科学基金会;
关键词：
C-H AMINATION; PHOTOREDOX CATALYSIS; FUNCTIONALIZATION; STRATEGIES; OXIDATION; BIDENTATE; CHEMISTRY; RADICALS; IODINE; OXYGEN;
D O I：
10.1021/acs.orglett.0c03934
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The cross-coupling of C-N bond directly from inert C-H bonds is an ideal approach to synthesize saturated azacycles due to its high efficiency and atom economy. In this article, a copper-catalyzed intramolecular amination via the cross coupling of C(sp(3))-H and N-H bonds of secondary amine has been reported, which exhibit excellent chemo- and regioselectivity, extensive substrate scope, and functional group tolerance in good to excellent yield, offering an efficient pathway to build nitrogen-containing heterocycle skeletons.
引用
收藏
页码：421 / 426
页数：6
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