Coupling mRNA Synthesis and Decay

被引：58

作者：

Braun, Katherine A. ^{[1
]}

Young, Elton T. ^{[1
]}

机构：

[1] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2014年 / 34卷 / 22期

基金：

美国国家卫生研究院;

关键词：

SNF1; PROTEIN-KINASE; SACCHAROMYCES-CEREVISIAE; POLYMERASE-II; GENE-EXPRESSION; TRANSCRIPTION TERMINATION; GLUCOSE REPRESSION; POSTTRANSCRIPTIONAL REGULATION; PROCESSING FACTORS; PUF PROTEINS; YEAST;

D O I：

10.1128/MCB.00535-14

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Posttranscriptional regulation of gene expression has an important role in defining the phenotypic characteristics of an organism. Well-defined steps in mRNA metabolism that occur in the nucleus-capping, splicing, and polyadenylation-are mechanistically linked to the process of transcription. Recent evidence suggests another link between RNA polymerase II ( Pol II) and a posttranscriptional process that occurs in the cytoplasm-mRNA decay. This conclusion appears to represent a conundrum. How could mRNA synthesis in the nucleus and mRNA decay in the cytoplasm be mechanistically linked? After a brief overview of mRNA processing, we will review the recent evidence for transcription-coupled mRNA decay and the possible involvement of Snf1, the Saccharomyces cerevisiae ortholog of AMP-activated protein kinase, in this process.

引用

页码：4078 / 4087

页数：10

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