Age-related trends in pathogen frequency and antimicrobial susceptibility of bloodstream isolates in North America SENTRY Antimicrobial Surveillance Program, 1997-2000

被引:77
作者
Diekema, DJ
Pfaller, MA
Jones, RN
机构
[1] Univ Iowa, Coll Med, Med Microbiol Div, Dept Pathol, Iowa City, IA 52242 USA
[2] Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA
[3] Tufts Univ, Sch Med, Boston, MA 02111 USA
[4] Jones Grp, JMI Labs, Iowa City, IA USA
关键词
antimicrobial resistance; surveillance; bloodstream infection;
D O I
10.1016/S0924-8579(02)00204-2
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We report age-related trends in pathogen frequency and antimicrobial susceptibility from 25,745 bloodstream infections (BSI) due to bacterial pathogens reported from medical centres participating in the North American SENTRY Antimicrobial Surveillance Program between January 1997 and September 2000. Staphylococcus aureus, Escherichia coli and coagulase-negative staphylococci (CoNS) were the most common pathogens, together accounting for 55% of all BSI pathogens during this time period. Among nosocomial BSI, CoNS were the most frequently isolated pathogens in infants less than I year of age, but S. aureus increased in frequency with increasing age. Among community-onset BSI pathogens, Streptococcus pneumoniae was the most frequently reported pathogen causing BSI in patients aged 1-5, S. aureus among those aged 6-64, and E. coli predominated at the extremes of age (less than I year and ! 65 years of age). Among key organism: antimicrobial agent combinations evaluated, oxacillin resistance in S. aureus increased with increasing age; conversely, oxacillin resistance among CoNS was highest among children 5 years of age or younger. Penicillin resistance among S. pneumoniae BSI was highest in children younger than 5 years, while vancomycin resistance among Enterococcus spp. predominated among nosocomial BSI in patients over 50 years of age. Important age-related differences exist in species distribution and antimicrobial susceptibility of pathogens causing BSI. This information should be helpful for clinicians as they consider empirical antimicrobial therapy for patients with suspected BSI across the age continuum. (C) 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
引用
收藏
页码:412 / 418
页数:7
相关论文
共 36 条
  • [1] Quinupristin/dalfopristin: A therapeutic review
    Allington, DR
    Rivey, MP
    [J]. CLINICAL THERAPEUTICS, 2001, 23 (01) : 24 - +
  • [2] [Anonymous], 1999, MMWR-MORBID MORTAL W, V48, P707
  • [3] Antimicrobial resistance in isolates from inpatients and outpatients in the united states: Increasing importance of the intensive care unit
    Archibald, L
    Phillips, L
    Monnet, D
    McGowan, JE
    Tenover, F
    Gaynes, R
    [J]. CLINICAL INFECTIOUS DISEASES, 1997, 24 (02) : 211 - 215
  • [4] BRYAN CS, 1983, REV INFECT DIS, V5, P629
  • [5] FACTORS AFFECTING MORTALITY OF GRAM-NEGATIVE ROD BACTEREMIA
    BRYANT, RE
    HOOD, AF
    HOOD, CE
    KOENIG, MG
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1971, 127 (01) : 120 - &
  • [6] Genetic relatedness of multidrug-resistant, methicillin (oxacillin)-resistant Staphylococcus aureus bloodstream isolates from SENTRY antimicrobial resistance surveillance centers worldwide, 1998
    Diekema, DJ
    Pfaller, MA
    Turnidge, J
    Verhoef, J
    Bell, J
    Fluit, AC
    Doern, GV
    Jones, RN
    [J]. MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 2000, 6 (03): : 213 - 221
  • [7] Trends in antimicrobial susceptibility of bacterial pathogens isolated from patients with bloodstream infections in the USA, Canada and Latin America
    Diekema, DJ
    Pfaller, MA
    Jones, RN
    Doern, GV
    Kugler, KC
    Beach, ML
    Sader, HS
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 13 (04) : 257 - 271
  • [8] Diekema DJ, 1999, CLIN INFECT DIS, V29, P595, DOI 10.1086/598640
  • [9] Oxazolidinone antibiotics
    Diekema, DJ
    Jones, RN
    [J]. LANCET, 2001, 358 (9297) : 1975 - 1982
  • [10] Survey of infections due to Staphylococcus species:: Frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999
    Diekema, DJ
    Pfaller, MA
    Schmitz, FJ
    Smayevsky, J
    Bell, J
    Jones, RN
    Beach, M
    [J]. CLINICAL INFECTIOUS DISEASES, 2001, 32 : S114 - S132