Prenylated Benzophenone Peroxide Derivatives from Hypericum sampsonii

被引：38

作者：

Xiao, Zhi Yong ^{[1
]}

Zeng, Yi Han ^{[1
]}

Mu, Qing ^{[1
]}

Shiu, Winnie Ka Po ^{[2
]}

Gibbons, Simon ^{[2
]}

机构：

[1] Fudan Univ, Sch Pharm, Shanghai 200032, Peoples R China

[2] Univ London, Sch Pharm, Ctr Pharmacognosy & Phytotherapy, London WC1N 1AX, England

来源：

CHEMISTRY & BIODIVERSITY | 2010年 / 7卷 / 04期

基金：

美国国家科学基金会;

关键词：

RESISTANT STAPHYLOCOCCUS-AUREUS; UNIQUE FAMILY; GUTTIFERAE;

D O I：

10.1002/cbdv.200900247

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new prenylated benzophenone peroxide derivatives, peroxysampsones A and B (1 and 2. resp.), together with a known compound, plukenetione C (3), were isolated from the roots of the Chinese medicinal plant Hypericum sampsonii, and their structures were elucidated by detailed spectral analysis. These compounds are the unusual peroxides of polyprenylated benzophenone derivatives, containing the unique caged moiety of 4,5-dioxatetracyclo[9.3. 1.1.(9.13).0(1.7)] hexadecane-12,14.15-trione. In the biological test, peroxysampsone A (I) showed comparable activity with norfloxacin against a NorA over-expressing multidrug-resistant (MDR) strain of Staphylococcus aurcus SA-1199B.

引用

页码：953 / 958

页数：6

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