Puerarin plays a protective role in chondrocytes by activating Beclin1-dependent autophagy

被引：17

作者：

Li, Guishuang ^{[1
]}

Rao, Hongming ^{[1
]}

Xu, Weihong ^{[1
]}

机构：

[1] Fujian Med Univ, Dept Orthoped, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2021年 / 85卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Puerarin; chondrocyte; osteoarthritis; autophagy; Beclin1; APOPTOSIS; RATS; P53;

D O I：

10.1093/bbb/zbaa078

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Puerarin can protect chondrocytes, whereby ameliorating osteoarthritis. Puerarin also promotes autophagy. Autophagy maintains chondrocyte homeostasis. The role of autophagy in puerarin-protected chondrocytes is unknown. Puerarin promoted chondrocyte autophagy. Puerarin-protected chondrocytes were reversed by autophagy inhibitors and Beclin1 inhibitor. 3-MA or Beclin1 inhibitor in vivo reversed puerarin-ameliorated cartilage damage of osteoarthritis mice. Thus, puerarin can protect chondrocytes through Beclin1-dependent autophagy activation.

引用

页码：621 / 625

页数：5

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