C-reactive protein as a risk factor versus risk marker

被引：45
作者：
de Maat, MPM
Trion, A
机构：
[1] Erasmus Univ, Med Ctr, Dept Hematol, NL-3015 GE Rotterdam, Netherlands
[2] TNO, Prevent & Hlth, Leiden, Netherlands
[3] Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands
来源：
CURRENT OPINION IN LIPIDOLOGY | 2004年 / 15卷 / 06期
关键词：
atherosclerosis; cardiovascular disease; C-reactive protein; inflammation; thrombosis;
D O I：
10.1097/00041433-200412000-00005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Purpose of review C-reactive protein (CRP) is consistently associated with cardiovascular disease in prospective and cross-sectional clinical and epidemiological studies. Inflammation is an important mechanism in cardiovascular disease, and the plasma level of CRP is considered to reflect the inflammatory condition of the patient and/or the vessel wall. In addition, there are also a number of indications for a causal role of CRP in cardiovascular disease. Recent findings A number of new publications show potential causal effects of CRP on cardiovascular disease, and evidence from human-CRP transgenic animals also indicates a causal contribution of CRP to cardiovascular disease. On the other hand, a new large prospective study and an updated meta-analysis indicate that the contribution of CRP to cardiovascular disease is less impressive than reported earlier (odds ratio, 1.58; 95% confidence interval, 1.48-1.68). Summary We review here the most recent evidence on mechanisms by which CRP is involved as a causal factor in the precipitation of cardiovascular disease. Evidence for such a role is accumulating.
引用
收藏
页码：651 / 657
页数：7
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