A Review of the Impact of Maternal Obesity on the Cognitive Function and Mental Health of the Offspring

被引：118

作者：

Contu, Laura ^{[1
]}

Hawkes, Cheryl A. ^{[1
]}

机构：

[1] Open Univ, Sch Life Hlth & Chem Sci, Sci Technol Engn & Math, Walton Hall, Milton Keynes MK7 6AA, Bucks, England

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 05期

关键词：

maternal obesity; high fat diet; offspring brain; mental health; cognitive function; epigenetics; HIGH-FAT DIET; BODY-MASS INDEX; GESTATIONAL WEIGHT-GAIN; PREPREGNANCY OBESITY; HIPPOCAMPAL NEUROGENESIS; CHILD NEURODEVELOPMENT; ANXIETY BEHAVIOR; GENE-EXPRESSION; CAFETERIA DIET; WESTERN DIET;

D O I：

10.3390/ijms18051093

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Globally, more than 20% of women of reproductive age are currently estimated to be obese. Children born to obese mothers are at higher risk of developing obesity, coronary heart disease, diabetes, stroke, and asthma in adulthood. Increasing clinical and experimental evidence suggests that maternal obesity also affects the health and function of the offspring brain across the lifespan. This review summarizes the current findings from human and animal studies that detail the impact of maternal obesity on aspects of learning, memory, motivation, affective disorders, attention-deficit hyperactivity disorder, autism spectrum disorders, and neurodegeneration in the offspring. Epigenetic mechanisms that may contribute to this mother-child interaction are also discussed.

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页数：11

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