Bioactive lipids in cancer stem cells

被引:22
作者
Begicevic, Romana-Rea [1 ]
Arfuso, Frank [2 ]
Falasca, Marco [1 ]
机构
[1] Curtin Univ, Curtin Hlth Innovat Res Inst, Sch Pharm & Biomed Sci, Metab Signalling Grp, GPO Box U1987, Perth, WA 6102, Australia
[2] Curtin Univ, Curtin Hlth Innovat Res Inst, Sch Pharm & Biomed Sci, Stem Cell & Canc Biol Lab, Perth, WA 6102, Australia
来源
WORLD JOURNAL OF STEM CELLS | 2019年 / 11卷 / 09期
关键词
Cancer stem cells; Lipid metabolism; Bioactive lipids; ABC transporters; STEAROYL-COA DESATURASE; OXIDATIVE-PHOSPHORYLATION; ABC TRANSPORTERS; HUMAN LEUKEMIA; CELLULAR PROLIFERATION; MULTIDRUG-RESISTANCE; SELF-RENEWAL; STATIN USE; METABOLISM; GLIOBLASTOMA;
D O I
10.4252/wjsc.v11.i9.693
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Tumours are known to be a heterogeneous group of cells, which is why they are difficult to eradicate. One possible cause for this is the existence of slow-cycling cancer stem cells (CSCs) endowed with stem cell-like properties of self-renewal, which are responsible for resistance to chemotherapy and radiotherapy. In recent years, the role of lipid metabolism has garnered increasing attention in cancer. Specifically, the key roles of enzymes such as stearoyl-CoA desaturase-1 and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in CSCs, have gained particular interest. However, despite accumulating evidence on the role of proteins in controlling lipid metabolism, very little is known about the specific role played by lipid products in CSCs. This review highlights recent findings on the role of lipid metabolism in CSCs, focusing on the specific mechanism by which bioactive lipids regulate the fate of CSCs and their involvement in signal transduction pathways.
引用
收藏
页码:693 / 704
页数:12
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