Soluble interleukin 6 receptor levels are associated with reduced myocardial reperfusion after percutaneous coronary intervention for acute myocardial infarction

被引：27

作者：

Groot, Hide E. ^{[1
]}

Hartman, Minke H. T. ^{[1
]}

Gu, Youlan L. ^{[1
]}

de Smet, Bart J. G. L. ^{[2
]}

van den Heuvel, Ad F. M. ^{[1
]}

Lipsic, Erik ^{[1
]}

van der Harst, Pim ^{[1
,3
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

[2] Meander Med Ctr, Dept Cardiol, Amersfoort, Netherlands

[3] ICIN Netherlands Heart Inst, Durrer Ctr Cardiovasc Res, Utrecht, Netherlands

来源：

CYTOKINE | 2015年 / 73卷 / 02期

关键词：

Soluble interleukin-6 receptor; Myocardial reperfusion; INDIVIDUAL PARTICIPANT METAANALYSIS; LEFT-VENTRICULAR FUNCTION; NO-REFLOW PHENOMENON; C-REACTIVE PROTEIN; HEART-DISEASE; ANGIOGRAPHIC ASSESSMENT; CLINICAL-IMPLICATIONS; PRIMARY ANGIOPLASTY; BLUSH GRADE; RISK;

D O I：

10.1016/j.cyto.2015.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aims: Interleukin-6 receptor (IL-6R) signalling has been suggested to play a causal role in the development and outcome of coronary heart disease (CHD). The aim of this study was to investigate the association of sIL-6R levels with myocardial reperfusion after percutaneous coronary intervention (PCI) for acute ST-elevated myocardial infarction (STEMI). Methods: Blood was sampled from 70 patients presenting with STEMI at 6 different time-points (baseline, post-PCI, t = 1 h, t = 6 h, t = 24 h, t = 2w). Coronary angiograms post-PCI were analysed for myocardial blush grade (MBG) as indicator of myocardial reperfusion. Serum IL-6 and sIL-6R were measured using IL-6 and sIL-6R enzyme-linked immunosorbent assays (ELISA). Results: sIL-6R levels fluctuated biphasic during the two weeks after STEMI. Reduced MBG was associated with a larger change in sIL-6R levels between baseline and post-PCI compared to optimal MBG (-13.40; SEM 2.78 ng/ml vs -1.99; SEM 2.35 ng/ml, respectively; p < 0.001). Patients with reduced MBG also showed a larger increase in sIL-6R levels after PCI and 1 h after myocardial infarction (MI) compared to optimal MBG (respectively 11.56: SEM 2.68 ng/ml vs 3.02; SEM 2.39 ng/ml; p = 0.018). IL-6/sIL-6R ratio was also more increased in patients with reduced MBG at 24 h after myocardial infarction (0.23; SEM 0.08-0.51 vs 0.10; SEM 0.05-0.21; p = 0.024). An optimal MBG was associated with a 10 ng increase in sIL-6R level between baseline and post-PCI (OR 1.687, CI 1.095-2.598; p = 0.018). Conclusions: sIL-6R levels fluctuate biphasic during the two weeks after MI with larger changes and increased IL-6/sIL-6R ratio in patients with reduced MBG. Further research is needed to increase our understanding of the possible causality of these associations. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：207 / 212

页数：6