Homing in on genomic instability as a therapeutic target in cancer

被引：20
作者：
Bielski, Craig M. [1 ,2 ,3 ]
Taylor, Barry S. [2 ,3 ,4 ,5 ]
机构：
[1] Weill Cornell Med Coll, New York, NY USA
[2] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA
[3] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA
[4] Mem Sloan Kettering Canc Ctr, Marie Josee & Henry R Kravis Ctr Mol Oncol, 1275 York Ave, New York, NY 10021 USA
[5] Loxo Oncol, Stamford, CT 06901 USA
来源：
NATURE COMMUNICATIONS | 2021年 / 12卷 / 01期
基金：
美国国家卫生研究院;
关键词：
CHROMOSOMAL INSTABILITY; ANEUPLOIDY;
D O I：
10.1038/s41467-021-23965-5
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
While genomic instability is a hallmark of cancer, its genetic vulnerabilities remain poorly understood. Identifying strategies that exploit genomic instability to selectively target cancer cells is a central challenge in cancer biology with major implications for anti-cancer drug development.
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页数：3
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