Zinc isotopic compositions of breast cancer tissue

被引：96

作者：

Larner, Fiona ^{[1
,2
]}

Woodley, Laura N. ^{[3
]}

Shousha, Sami ^{[4
]}

Moyes, Ashley ^{[5
]}

Humphreys-Williams, Emma ^{[6
]}

Strekopytov, Stanislav ^{[6
]}

Halliday, Alex N. ^{[1
]}

Rehkaemper, Mark ^{[2
]}

Coombes, R. Charles ^{[7
]}

机构：

[1] Univ Oxford, Dept Earth Sci, Oxford OX1 3AN, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Earth Sci & Engn, London SW7 2AZ, England

[3] Univ London Imperial Coll Sci Technol & Med, Expt Canc Med Ctr Network, London W6 8RF, England

[4] Univ London Imperial Coll Sci Technol & Med, Charing Cross Hosp, Dept Histopathol, London W6 8RF, England

[5] Imperial Coll NHS Trust, Charing Cross Hosp, London W6 8RF, England

[6] Nat Hist Museum, Dept Earth Sci, London SW7 5BD, England

[7] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, London W12 0NN, England

来源：

METALLOMICS | 2015年 / 7卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

CU; FE; COPPER; BLOOD; ZN;

D O I：

10.1039/c4mt00260a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An early diagnostic biomarker for breast cancer is essential to improve outcome. High precision isotopic analysis, originating in Earth sciences, can detect very small shifts in metal pathways. For the first time, the natural intrinsic Zn isotopic compositions of various tissues in breast cancer patients and controls were determined. Breast cancer tumours were found to have a significantly lighter Zn isotopic composition than the blood, serum and healthy breast tissue in both groups. The Zn isotopic lightness in tumours suggests that sulphur rich metallothionein dominates the isotopic selectivity of a breast tissue cell, rather than Zn-specific proteins. This reveals a possible mechanism of Zn delivery to Zn-sequestering vesicles by metallothionein, and is supported by a similar signature observed in the copper isotopic compositions of one breast cancer patient. This change in intrinsic isotopic compositions due to cancer has the potential to provide a novel early biomarker for breast cancer.

引用

页码：107 / 112

页数：6

共 28 条

[1] Cellular Mechanisms of Zinc Dysregulation: A Perspective on Zinc Homeostasis as an Etiological Factor in the Development and Progression of Breast Cancer [J].