Improving Objective Measurements of the Tumour-Stroma Ratio in Breast Cancer Using Polarized Light Microscopy

被引：0
作者：
Sprenger, Jillian [1 ]
Murray, Ciara [2 ]
Lad, Jigar [1 ]
Jones, Blake [1 ]
Thomas, Georgia [1 ]
Nofech-Mozes, Sharon [3 ]
Khorasani, Mohammadali [4 ]
Vitkin, Alex [1 ,5 ]
机构：
[1] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
[2] Univ Hlth Network, Lab Med Program, Toronto, ON, Canada
[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[4] Univ British Columbia, Dept Surg, Victoria, BC, Canada
[5] Univ Toronto, Dept Radiat Oncol, Toronto, ON, Canada
来源：
ADVANCES IN MICROSCOPIC IMAGING III | 2021年 / 11922卷
关键词：
INDEPENDENT PREDICTOR; SURVIVAL; CELLS;
D O I：
10.1117/12.2615729
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Polarized light microscopy can be used to objectively quantify tumour-stroma ratio (TSR), a prognostic indicator validated in several cancers. Polarimetric results correctly differentiated between high- and low-stroma samples, and future work holds promise for improved separation.
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页数：3
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共 14 条
  • [1] Tumor-Stroma Ratio is an independent predictor for overall survival and disease free survival in gastric cancer patients
    Aurello, Paolo
    Berardi, Giammauro
    Giulitti, Diego
    Palumbo, Antonio
    Tierno, Simone Maria
    Nigri, Giuseppe
    D'Angelo, Francesco
    Pilozzi, Emanuela
    Ramacciato, Giovanni
    [J]. SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND, 2017, 15 (06): : 329 - 335
  • [2] Why the stroma matters in breast cancer Insights into breast cancer patient outcomes through the examination of stromal biomarkers
    Conklin, Matthew W.
    Keely, Patricia J.
    [J]. CELL ADHESION & MIGRATION, 2012, 6 (03) : 249 - 260
  • [3] The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer
    Downey, C. L.
    Simpkins, S. A.
    White, J.
    Holliday, D. L.
    Jones, J. L.
    Jordan, L. B.
    Kulka, J.
    Pollock, S.
    Rajan, S. S.
    Thygesen, H. H.
    Hanby, A. M.
    Speirs, V.
    [J]. BRITISH JOURNAL OF CANCER, 2014, 110 (07) : 1744 - 1747
  • [4] Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
    Hanahan, Douglas
    Coussens, Lisa M.
    [J]. CANCER CELL, 2012, 21 (03) : 309 - 322
  • [5] Peri-tumoural stroma collagen organization of invasive ductal carcinoma assessed by polarized light microscopy differs between OncotypeDX risk group
    Jones, Blake
    Thomas, Georgia
    Sprenger, Jillian
    Nofech-Mozes, Sharon
    Khorasani, Mohammadali
    Vitkin, Alex
    [J]. JOURNAL OF BIOPHOTONICS, 2020, 13 (11)
  • [6] Novel quantitative signature of tumor stromal architecture: polarized light imaging differentiates between myxoid and sclerotic human breast cancer stroma
    Jones, Blake
    Thomas, Georgia
    Westreich, Jared
    Nofech-Mozes, Sharon
    Vitkin, Alex
    Khorasani, Mohammadali
    [J]. BIOMEDICAL OPTICS EXPRESS, 2020, 11 (06) : 3246 - 3262
  • [7] The prognostic value of tumour-stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review
    Kramer, C. J. H.
    Vangangelt, K. M. H.
    van Pelt, G. W.
    Dekker, T. J. A.
    Tollenaar, R. A. E. M.
    Mesker, W. E.
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2019, 173 (01) : 55 - 64
  • [8] Mesker WE, 2007, CELL ONCOL, V29, P387
  • [9] Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study
    Scheer, Rene
    Baidoshvili, Alexi
    Zoidze, Shorena
    Elferink, Marloes A. G.
    Berkel, Annefleur E. M.
    Klaase, Joost M.
    van Diest, Paul J.
    [J]. WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2017, 9 (12) : 466 - 474
  • [10] Sprenger J., 2021, BIOMED OPT EXPRESS
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