Chromosome 9p and 10q losses predict unfavorable outcome in low-grade gliomas

被引：20
作者：
Houillier, Caroline [1 ]
Mokhtari, Karima [2 ,3 ]
Carpentier, Catherine [2 ]
Criniere, Ernmanuelle [2 ]
Marie, Yannick [2 ]
Rousseau, Audrey [2 ,3 ]
Kaloshi, Gentian [1 ]
Dehais, Caroline [1 ]
Laffaire, Julien [2 ]
Laigle-Donadey, Florence [1 ,2 ]
Hoang-Xuan, Khe [1 ,2 ]
Sanson, Marc [1 ,2 ]
Delattre, Jean-Yves [1 ,2 ]
机构：
[1] Grp Hosp Pitie Salpetriere, AP HP, Serv Neurol 2 Mazarin, F-75651 Paris 13, France
[2] Univ Paris 06, INSERM, U975, Fac Med Pitie Salpetriere,CNRS,UMR 7225, F-75252 Paris, France
[3] Grp Hosp Pitie Salpetriere, AP HP, Lab Neuropathol R Escourolle, F-75651 Paris 13, France
来源：
NEURO-ONCOLOGY | 2010年 / 12卷 / 01期
关键词：
chromosomes 9p and 10q; low-grade gliomas; prognosis; COMPARATIVE GENOMIC HYBRIDIZATION; OLIGODENDROGLIAL TUMORS; RADIATION-THERAPY; PROGNOSTIC-FACTOR; RANDOMIZED TRIAL; SURVIVAL; 1P; HETEROZYGOSITY; GLIOBLASTOMAS; PROGRESSION;
D O I：
10.1093/neuonc/nop002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The loss of chromosomes 1p-19q is the only prognostic molecular alteration identified in low-grade gliomas (LGGs) to date. Search for loss of heterozygosity (LOH) on chromosomes 1p, 9p, 10q, and 19q was performed in a series of 231 LGGs. Loss of chromosomes 1p-19q was strongly correlated with prolonged progression-free survival (PFS) and overall survival (OS) in univariate and multivariate analyses. LOH on 9p and 10q were associated with shortened PFS (P = .01 and .03, respectively) on univariate analysis. On multivariate analysis, LOH on 9p remained significant for PFS (P = .05), whereas LOH on 10q had a significant effect on OS (P = .02). Search for LOH 9p and 10q appears to be a useful complement to analysis of chromosomes 1p-19q in LGGs.
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收藏
页码：2 / 6
页数：5
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