STAM2, a new member of the STAM family, binding to the Janus kinases

被引：66

作者：

Endo, K

Takeshita, T

Kasai, H

Sasaki, Y

Tanaka, N

Asao, H

Kikuchi, K

Yamada, M

Chen, M

O'Shea, JJ

Sugamura, K

机构：

[1] Tohoku Univ, Sch Med, Dept Microbiol & Immunol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] NIAMSD, Lymphocyte Cell Biol Sect, Arthrit & Rheumatism Branch, NIH, Bethesda, MD 20892 USA

[3] Japan Sci & Technol Corp, CREST, Tokyo, Japan

来源：

FEBS LETTERS | 2000年 / 477卷 / 1-2期

关键词：

IL-2; GM-CSF; signal transduction; tyrosine kinase;

D O I：

10.1016/S0014-5793(00)01760-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We here cloned a cDNA encoding STAM2, a new member of the STAM family, which contains an SH3 domain and ITAM, STAM2 like STAM1 is associated with Jak2 and Jak3, and involved in the signaling for DNA synthesis and c-myc induction mediated by IL-2 and GM-CSF. Go-expression of the SH3 deletion mutants of STAM1 and STAM2 induces an additive effect on suppressing DNA synthesis upon stimulation with IL-2 and GM-CSF, suggesting that STAM1 and STAM2 exhibit compensatory effects on the signaling pathways downstream of Jak2 and Jak3 upon stimulation with GM-SCF and IL-2, respectively, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

收藏

页码：55 / 61

页数：7

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