Cannabinoids, hippocampal excitability and efficacy for the treatment of epilepsy

被引：3
作者：
Yao, Isaac [1 ,2 ]
Stein, Efrat Shavit [1 ]
Maggio, Nicola [1 ,2 ,3 ]
机构：
[1] Chaim Sheba Med Ctr Tel Hashomer, Dept Neurol, IL-52621 Ramat Gan, Israel
[2] Tel Aviv Univ, Dept Neurol & Neurosurg, Sackler Fac Med, IL-6997801 Tel Aviv, Israel
[3] Chaim Sheba Med Ctr Tel HaShomer, Talpiot Med Leadership Program, IL-52621 Tel Hashomer, Israel
来源：
PHARMACOLOGY & THERAPEUTICS | 2019年 / 202卷
关键词：
Cannabis; Cannabidiol; (THC)-T-9; Epilepsy; Hippocampus; Therapy; GLUTAMATERGIC SYNAPTIC-TRANSMISSION; TREATMENT-RESISTANT EPILEPSY; ENDOCANNABINOID SYSTEM; PEDIATRIC EPILEPSY; CB1; RECEPTORS; GABAERGIC INTERNEURONS; FUNCTIONAL EXPRESSION; ACETYLCHOLINE-RELEASE; INDUCED SEIZURES; CANNABIDIOL;
D O I：
10.1016/j.pharmthera.2019.06.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Interest in cannabis and its related cannabinoids THC and CBD for use as anti-convulsant therapy has been progressively increasing. While the destigmatization of cannabis and cannabis related research have progressed in the last few decades, there are still many questions that remain unanswered. This review seeks to summarize the progress made in cannabis research in the past four decades and to identify possible directions for future research that are critical for the development of cannabinoid-based therapy in epilepsy. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页码：32 / 39
页数：8
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