Zw10 negatively regulates the MyD88-mediated NF-xB signaling through autophagy in teleost fish

被引：7

作者：

Cao, Baolan ^{[1
]}

Chen, Ya ^{[1
]}

Cui, Junxia ^{[1
]}

Sun, Yuena ^{[1
,3
,4
]}

Xu, Tianjun ^{[1
,2
,3
,4
]}

机构：

[1] Shanghai Ocean Univ, Coll Fisheries & Life Sci, Lab Fish Mol Immunol, Shanghai, Peoples R China

[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China

[3] Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai, Peoples R China

[4] Shanghai Ocean Univ, Natl Pathogen Collect Ctr Aquat Anim, Shanghai, Peoples R China

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2022年 / 132卷

关键词：

MyD88; Zw10; NF-xB; Autophagy; Teleost fish; TOLL-LIKE RECEPTORS; KAPPA-B PATHWAY; MEMBRANE TRAFFICKING; PROTEIN; MYD88; LOCALIZATION; RECOGNITION; DEGRADATION; ACTIVATION; IMMUNITY;

D O I：

10.1016/j.dci.2022.104401

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

MyD88 is a typical street protein of the TLRs signaling pathway and is a central player in innate immune signaling, which can regulate the NF-xB signaling pathway and promote downstream inflammatory factors. However, studies on the molecular mechanisms of the MyD88-mediated NF-xB signaling pathway in teleosts have been poorly reported. In this study, we report that Zw10 targets MyD88 to inhibit NF-xB activation. Zw10 inhibits cell proliferation and MyD88-mediated innate immunity in fish. Zw10 interacts with MyD88, and its A2 domain is very critical for MyD88 degradation. In addition, we found that Zw10 degrade MyD88 by autophagy, thereby negatively regulating the MyD88-mediated NF-xB signaling pathway. This study not only enriches the research on the innate immunity of teleost fish, but also provides insights for the regulating mechanism for mammals.

引用

页数：8

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