Single chain observation on collapse transition in giant DNA induced by negatively-charged polymer

被引：16

作者：

Ichiba, Y ^{[1
]}

Yoshikawa, K ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Human Informat, Div Informat Nat Sci, Nagoya, Aichi 46401, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 242卷 / 02期

关键词：

D O I：

10.1006/bbrc.1997.7967

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly-glutamic acid, a polyanion, has been shown to induce the all-or-none collapse transition in individual duplex DNAs from an elongated coil into a collapsed compact state, through the observation of single chains by fluorescence microscopy. This experimental finding is discussed in relation to the change in the higher-order structure of DNAs in the cytoplasmic space induced by a change in the concentration of polyanions, such as mRNA, as a possible route for feedback in gene expression. (C) 1998 Academic Press.

引用

页码：441 / 445

页数：5

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