Antibacterial activity of poly(vinyl alcohol)-b-poly(acrylonitrile) based micelles loaded with silver nanoparticles

被引：42
|
作者：
Bryaskova, Rayna [1 ]
Pencheva, Daniela [2 ]
Kyulavska, Mariya [1 ]
Bozukova, Dimitriya [3 ]
Debuigne, Antoine [3 ]
Detrembleur, Christophe [3 ]
机构：
[1] Univ Chem Technol & Met, Dept Polymer Engn, BU-1756 Sofia, Bulgaria
[2] Bul Bionatl Ctr Infect & Parasit Dis, Sofia 1504, Bulgaria
[3] Univ Liege, CERM, B-4000 Liege, Belgium
来源：
JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2010年 / 344卷 / 02期
关键词：
Block copolymers; Micelles; Silver; Nanoparticles; Antibacterial activity; Minimum bactericidal concentration; AMPHIPHILIC BLOCK-COPOLYMERS; FABRICATION; MECHANISM; ARRAYS;
D O I：
10.1016/j.jcis.2009.12.040
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A new amphiphilic poly(vinyl alcohol)-b-poly(acrylonitrile) (PVOH-b-PAN) copolymer obtained by selective hydrolysis of well-defined poly(vinyl acetate)-b-poly(acrylonitrile) copolymer synthesized by cobalt mediated radical polymerization was used for the preparation of PVOH-b-PAN based micelles with embedded silver nanoparticles. The successful formation of silver loaded micelles has been confirmed by UV-vis, DLS and TEM analysis and their antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa) and spore solution of Bacillus subtilis (B. subtilis) has been studied. PVOH-b-PAN based micelles with embedded silver nanoparticles showed a strong bactericidal effect against E. coli, S. aureus and P. aeruginosa and the minimum bactericidal concentration for each system (MBC) has been determined. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：424 / 428
页数：5
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