NHC Catalyzed Oxidations of Aldehydes to Esters: Chemoselective Acylation of Alcohols in Presence of Amines

被引：341

作者：

De Sarkar, Suman ^{[1
]}

Grimme, Stefan ^{[1
]}

Studer, Armido ^{[1
]}

机构：

[1] Univ Munster, Organisch Chem Inst, NRW Grad Sch Chem, D-48149 Munster, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 04期

关键词：

STEREOSELECTIVE-SYNTHESIS; ACTIVATED CARBOXYLATES; SELECTIVE ACYLATION; ESTERIFICATION; GENERATION; CONVERSION; AMIDATION; PEPTIDES;

D O I：

10.1021/ja910540j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Not just one but two carbenes of the same structure act cooperatively in oxidative acylations of alcohols with aldehydes by using a readily available cheap organic oxidant. Alcohols are selectively acylated in the presence of amines by cooperative carbene catalysis. Quantum chemical calculations Support the suggested mechanism.

引用

页码：1190 / +

页数：4

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