Lens opacities, demographic factors and nutritional supplements in the Barbados Eye Study

被引:48
作者
Leske, MC
Wu, SY
Connell, AMS
Hyman, L
Schachat, AP
机构
[1] SUNY Stony Brook, Hlth Sci Ctr, Dept Prevent Med, Med Ctr, Stony Brook, NY 11794 USA
[2] Minist Hlth, Bridgetown, Barbados
[3] Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21205 USA
关键词
lens changes; cortical opacities; nuclear opacities; nutritional supplements; demographic factors;
D O I
10.1093/ije/26.6.1314
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background. This study evaluated the association of age-related lens opacities with the use of nutritional supplements and demographic factors among 4314 black participants (greater than or equal to 40 years) in the population-based Barbados Eye Study. Methods. Lenses were classified at the slit lamp by the Lens Opacities Classification System II (LOCS II); a score greater than or equal to 2 was used to define the presence of gradable lens opacities, by type. Lens changes also included prior cataract surgery or cataract too advanced to grade. Associations with risk factors were evaluated by logistic regression analyses. Results. The study identified 1800 individuals with lens changes in at least one eye; 229 had nuclear opacities only; 851 had cortical opacities only. Older age and indicators of lower socioeconomic status (low education and/or non-professional occupation), were positively associated with both nuclear (odds ratio [OR] = 1.90) and cortical (OR = 1.47) opacities. Women had an increased risk of cortical opacities (OR = 1.41). Regular users of nutritional supplements were less likely to have lens changes (OR = 0.78) and, specifically, cortical opacities (OR = 0.77). The association with nutritional supplements was present in those <70 years, but not at older ages. Conclusions. The study supports the association of lower socioeconomic status with lens changes, including nuclear and cortical lens opacities. The findings also suggest that regular users of nutritional supplements have a one-fourth lower risk of lens changes and particularly, of cortical opacities; a result seen at ages under 70 years. The associations with potentially modifiable factors indicate the need for further evaluations, given the high prevalence of lens opacities.
引用
收藏
页码:1314 / 1322
页数:9
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