Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition

被引：26

作者：

Alaribe, Chinwendum Stephenie ^{[1
]}

Esposito, Tiziana ^{[2
]}

Sansone, Francesca ^{[2
]}

Sunday, Adesegun ^{[1
]}

Pagano, Imma ^{[2
]}

Piccinelli, Anna Lisa ^{[2
]}

Celano, Rita ^{[2
]}

Cuesta Rubio, Osmany ^{[3
]}

Coker, Herbert Alexander ^{[1
]}

Nabavi, Seyed Mohammad ^{[4
]}

Rastrelli, Luca ^{[2
]}

Picerno, Patrizia ^{[2
]}

机构：

[1] Univ Lagos, Dept Pharmaceut Chem, Fac Pharm, Lagos, Nigeria

[2] Univ Salerno, Dept Pharm, Salerno, Italy

[3] Tech Univ Machala, Chem & Hlth Fac, Ave Panamer Via Pasaje Km, Machala, Ecuador

[4] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 18期

关键词：

Nigerian propolis; polyphenols; free-radical scavenging activity; alpha-amylase and alpha-glucosidase enzymes; Helicobacter pylori; RED PROPOLIS;

D O I：

10.1080/14786419.2019.1682576

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4 and 7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect against alpha-amylase and alpha-glucosidase enzymes. Finally, NP showed also a moderate inhibition of Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products.

引用

页码：3095 / 3099

页数：5

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