ST2: a novel biomarker for heart failure

被引：24

作者：

Bhardwaj, Anju ^{[1
]}

Januzzi, James L., Jr. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2010年 / 10卷 / 04期

关键词：

B-type natriuretic peptide; biomarker; dyspnea; heart failure; myocardial infarction; pro-B-type natriuretic peptide; prognosis; ST2; RECEPTOR FAMILY-MEMBER; SOLUBLE ST2; PLASMA-CONCENTRATIONS; 1-YEAR MORTALITY; GENE-EXPRESSION; SERUM-LEVELS; DIAGNOSIS; PATHWAY; IL-33;

D O I：

10.1586/ERM.10.25

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

ST2, an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2) isoforms, was originally described in the context of inflammatory and autoimmune diseases. However, after the identification of IL-33 as the functional ligand for ST2, and conceptualization of the role of ST2/IL-33 signaling in cardiac remodeling, sST2 has emerged as a novel cardiovascular biomarker for the presence of ventricular biomechanical overload. Concentrations of sST2 have been implicated in the presence and severity of heart failure with particular value for prognostication. We will review the use of sST2 as a prognostic marker in heart failure, including present and future directions in this exciting area.

引用

页码：459 / 464

页数：6

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