Novel universal influenza virus vaccine approaches

被引：82
作者：
Krammer, Florian [1 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA
来源：
CURRENT OPINION IN VIROLOGY | 2016年 / 17卷
关键词：
HEMAGGLUTININ STALK ANTIBODIES; DEPENDENT CELLULAR CYTOTOXICITY; SERUM IMMUNOGLOBULIN LEVELS; HUMAN MONOCLONAL-ANTIBODY; NEUTRALIZING ANTIBODIES; REACTIVE ANTIBODIES; CONSTRUCTS PROTECT; GLOBULAR HEAD; DOMAIN; MICE;
D O I：
10.1016/j.coviro.2016.02.002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Seasonal influenza virus vaccines have to be re-formulated and re-administered on an annual basis due to antigenic drift of the influenza virus surface glycoproteins. In addition, seasonal vaccines show limited efficacy against novel pandemic influenza virus strains, and producing tailored vaccines for these strains in a timely manner is challenging. Several novel broadly protective vaccine candidates targeting the conserved stalk domain of the viral hemagglutinin have been developed. Here we review these novel constructs and discuss several important findings and considerations regarding the protective efficacy of stalk-based vaccines.
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收藏
页码：95 / 103
页数：9
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