The aim of this paper is to investigate the efficiency of a hybrid coagulation-microfiltration process for the removal of copper from a synthetic wastewater in comparison with the application of microfiltration alone. The wastewater samples contained various concentrations of humic acids, kaolin (clay), and Cu2+ ions in tap water. The effect of the concentrations of the constituents on the performance of microfiltration is examined. The efficiency of microfiltration was evaluated by measuring several parameters, including residual Cu2+ concentration, residual turbidity, residual humic acids concentration, pH, conductivity, and alkalinity. A conventional inorganic salt (Fe-2(SO4)(3)) and a novel composite inorganic-organic coagulant (PFS-PAA) were applied as coagulation agents to further enhance the microfiltration efficiency. The results show that membrane microfiltration is very efficient in treating such wastewaters, while the hybrid process exhibits even better performance, when compared to microfiltration.