Ultrasmall Superparamagnetic Iron Oxide Imaging Identifies Tissue and Nerve Inflammation in Pain Conditions

被引:8
作者
Shen, Shiqian [1 ]
Ding, Weihua [2 ]
Ahmed, Shihab [1 ]
Hu, Ranliang [3 ]
Opalacz, Arissa [1 ]
Roth, Sarah [1 ]
You, Zerong [1 ]
Wotjkiewicz, Gregory R. [4 ]
Lim, Grewo [1 ]
Chen, Lucy [1 ]
Mao, Jianren [1 ]
Chen, John W. [4 ]
Zhang, Yi [1 ]
机构
[1] Harvard Med Sch, MGH Ctr Translat Pain Res, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA
[2] Zhejiang Univ, Dept Anesthesia & Pain Med, Sch Med, Hangzhou, Zhejiang, Peoples R China
[3] Emory Univ Hosp, Dept Radiol & Imaging Sci, 1364 Clifton Rd NE, Atlanta, GA 30322 USA
[4] Harvard Med Sch, Massachusetts Gen Hosp, Inst Innovat Imaging, Dept Radiol, Boston, MA 02114 USA
基金
美国国家卫生研究院;
关键词
Inflammation; Imaging; Pain; USPIO; EPIDURAL STEROID INJECTIONS; TUMOR-NECROSIS-FACTOR; NEUROPATHIC PAIN; SCIATICA; TRIALS; MRI;
D O I
10.1093/pm/pnx267
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Objective. Correlation between radiologic structural abnormalities and clinical symptoms in low back pain patients is poor. There is an unmet clinical need to image inflammation in pain conditions to aid diagnosis and guide treatment. Ferumoxytol, an ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle, is clinically used to treat iron deficiency anemia and showed promise in imaging tissue inflammation in human. We explored whether ferumoxytol can be used to identify tissue and nerve inflammation in pain conditions in animals and humans. Methods. Complete Freud's adjuvant (CFA) or saline was injected into mice hind paws to establish an inflammatory pain model. Ferumoxytol (20mg/kg) was injected intravenously. Magnetic resonance imaging (MRI) was performed prior to injection and 72hours postinjection. The changes in the transverse relaxation time (T2) before and after ferumoxytol injection were compared between mice that received CFA vs saline injection. In the human study, we administered ferumoxytol (4mg/kg) to a human subject with clinical symptoms of lumbar radiculopathy and compared the patient with a healthy subject. Results. Mice that received CFA exhibited tissue inflammation and pain behaviors. The changes in T2 before and after ferumoxytol injection were significantly higher in mice that received CFA vs saline (20.8 +/- 3.6 vs 2.2 +/- 2.5, P=0.005). In the human study, ferumoxytolenhanced MRI identified the nerve root corresponding to the patient's symptoms, but the nerve root was not impinged by structural abnormalities, suggesting the potential superiority of this approach over conventional structural imaging techniques. Conclusions. Ferumoxytol-enhanced MRI can identify tissue and nerve inflammation and may provide a promising diagnostic tool in assessing pain conditions in humans.
引用
收藏
页码:686 / 692
页数:7
相关论文
共 19 条
  • [1] Abdi Salahadin, 2007, Pain Physician, V10, P185
  • [2] Assessment: Use of epidural steroid injections to treat radicular lumbosacral pain - Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    Armon, Carmel
    Argoff, Charles E.
    Samuels, Jeffrey
    Backonja, Misha-Miroslav
    [J]. NEUROLOGY, 2007, 68 (10) : 723 - 729
  • [3] Defining neuropathic pain
    Backonja, MM
    [J]. ANESTHESIA AND ANALGESIA, 2003, 97 (03) : 785 - 790
  • [4] Epidural Injections for Spinal Pain A Systematic Review and Meta-analysis Evaluating the "Control" Injections in Randomized Controlled Trials
    Bicket, Mark C.
    Gupta, Anita
    Brown, Charlie H.
    Cohen, Steven P.
    [J]. ANESTHESIOLOGY, 2013, 119 (04) : 907 - 931
  • [5] QUANTITATIVE ASSESSMENT OF TACTILE ALLODYNIA IN THE RAT PAW
    CHAPLAN, SR
    BACH, FW
    POGREL, JW
    CHUNG, JM
    YAKSH, TL
    [J]. JOURNAL OF NEUROSCIENCE METHODS, 1994, 53 (01) : 55 - 63
  • [6] SDF-1 Blockade Enhances Anti-VEGF Therapy of Glioblastoma and Can Be Monitored by MRI
    Deng, Lei
    Stafford, Jason H.
    Liu, Shie-Chau
    Chernikova, Sophia B.
    Merchant, Milton
    Recht, Lawrence
    Brown, J. Martin
    [J]. NEOPLASIA, 2017, 19 (01): : 1 - 7
  • [7] Magnetic Resonance Imaging in Follow-up Assessment of Sciatica
    el Barzouhi, Abdelilah
    Vleggeert-Lankamp, Carmen L. A. M.
    Nijeholt, Geert J. Lycklama A.
    Van der Kallen, Bas F.
    van den Hout, Wilbert B.
    Jacobs, Wilco C. H.
    Koes, Bart W.
    Peul, Wilco C.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (11) : 999 - 1007
  • [8] Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients
    Gaglia, Jason L.
    Harisinghani, Mukesh
    Aganj, Iman
    Wojtkiewicz, Gregory R.
    Hedgire, Sandeep
    Benoist, Christophe
    Mathis, Diane
    Weissleder, Ralph
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (07) : 2139 - 2144
  • [9] Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
    Gaglia, Jason L.
    Guimaraes, Alexander R.
    Harisinghani, Mukesh
    Turvey, Stuart E.
    Jackson, Richard
    Benoist, Christophe
    Mathis, Diane
    Weissleder, Ralph
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (01) : 442 - 445
  • [10] The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation
    Inglis, JJ
    Nissim, A
    Lees, DM
    Hunt, SP
    Chernajovsky, Y
    Kidd, BL
    [J]. ARTHRITIS RESEARCH & THERAPY, 2005, 7 (04) : R807 - R816