Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma

被引：224
作者：
Oberoi, Rajneet K. [1 ]
Parrish, Karen E. [1 ]
Sio, Terence T. [2 ]
Mittapalli, Rajendar K. [1 ]
Elmquist, William F. [1 ]
Sarkaria, Jann N. [2 ]
机构：
[1] Univ Minnesota, Coll Pharm, Dept Pharmaceut, Minneapolis, MN USA
[2] Mayo Clin, Dept Radiat Oncol, Rochester, MN USA
来源：
NEURO-ONCOLOGY | 2016年 / 18卷 / 01期
关键词：
blood-brain barrier; drug delivery; efflux transporters; glioma; CANCER RESISTANCE PROTEIN; P-GLYCOPROTEIN ABCB1; SOLID LIPID NANOPARTICLES; CENTRAL-NERVOUS-SYSTEM; FOCUSED-ULTRASOUND; PHASE-I; TARGETED THERAPY; MEDIATED EFFLUX; DISRUPTION; GLIOMA;
D O I：
10.1093/neuonc/nov164
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glioblastoma (GBM) is a lethal and aggressive brain tumor that is resistant to conventional radiation and cytotoxic chemotherapies. Molecularly targeted agents hold great promise in treating these genetically heterogeneous tumors, yet have produced disappointing results. One reason for the clinical failure of these novel therapies can be the inability of the drugs to achieve effective concentrations in the invasive regions beyond the bulk tumor. In this review, we describe the influence of the blood-brain barrier on the distribution of anticancer drugs to both the tumor core and infiltrative regions of GBM. We further describe potential strategies to overcome these drug delivery limitations. Understanding the key factors that limit drug delivery into brain tumors will guide future development of approaches for enhanced delivery of effective drugs to GBM.
引用
收藏
页码：27 / 36
页数：10
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