Relationship between the action of reactive oxygen and nitrogen species on bilayer membranes and antioxidants

被引：29
|
作者：
de Lima, VR
Morfim, MP
Teixeira, A
Creczynski-Pasa, TB
机构：
[1] Univ Fed Santa Catarina, Ctr Ciencias Saude, Dept Ciencias Farmaceut, BR-88040900 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Quim, Ctr Ciencias Fis & Matemat, BR-88040900 Florianopolis, SC, Brazil
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 2004年 / 132卷 / 02期
关键词：
reactive oxygen species; reactive nitrogen species; antioxidants; lipid peroxidation; differential scanning calorimetry; melatonin;
D O I：
10.1016/j.chemphyslip.2004.07.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Membrane lipid peroxidation (LPO) induced by hydroxyl ((OH)-O-.) and ascorbyl ((.)Asc) radicals and by peroxynitrite (ONOO-) was investigated in asolectin (ASO), egg phosphatidylcholine (PC) and PC/phosphatidic acid mixtures (PC:PA) liposomes and rat liver microsomes (MC). Enthalpy variation (DeltaH) of PC:PA at different molar ratios were obtained by differential scanning calorimetry. It was also evaluated the LPO inhibition by quercetin, melatonin and Vitamin B-6. The oxidant effect power follows the order (OH)-O-. approximate to .Asc > ONOO- on PC and MC; whilst on ASO liposomes, it follows (.)Asc > (OH)-O-. approximate to ONOO-. Increasing amounts of PA in PC liposomes resulted in lower levels of LPO. The DeltaH values indicate a more ordered membrane arrangement as a function of PA amount. The results were discussed in order to provide a complete view involving the influence of membranes, oxidants and antioxidants intrinsic behavior on the LPO dynamics. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：197 / 208
页数：12
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