Circular RNAs and Hepatocellular Carcinoma: New Epigenetic Players With Diagnostic and Prognostic Roles

被引：19

作者：

Aishanjiang, Kedeerya ^{[1
,2
]}

Wei, Xin-dong ^{[3
]}

Fu, Yi ^{[1
]}

Lin, Xinjie ^{[1
]}

Ma, Yujie ^{[1
]}

Le, Jiamei ^{[1
]}

Han, Qiuqin ^{[1
]}

Wang, Xuan ^{[3
]}

Kong, Xiaoni ^{[4
]}

Gu, Jinyang ^{[2
]}

Wu, Hailong ^{[1
,5
,6
]}

机构：

[1] Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Dept Collaborat Innovat Ctr Biomed, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Transplantat, Shanghai, Peoples R China

[3] Nanjing Univ Tradit Chinese Med, Hosp 81, Dept Gen Surg, Nanjing, Peoples R China

[4] Shanghai Univ Tradit Chinese Med, ShuGuang Hosp, Cent Lab, Inst Clin Immunol,Dept Liver Dis, Shanghai, Peoples R China

[5] Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai, Peoples R China

[6] Shanghai Univ Med & Hlth Sci, Collaborat Innovat Ctr Biomed, Shanghai, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

circular RNAs; hepatocellular carcinoma; biomarkers for diagnosis and prognosis; oncogenic circRNAs; tumor suppressive circRNAs; drug resistance; CANCER; CIRCRNAS; INSIGHTS; LONG;

D O I：

10.3389/fonc.2021.653717

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Due to the lack of potent diagnosis and prognosis biomarkers and effective therapeutic targets, the overall prognosis of survival is poor in HCC patients. Circular RNAs (circRNAs) are a class of novel endogenous non-coding RNAs with covalently closed loop structures and implicated in diverse physiological processes and pathological diseases. Recent studies have demonstrated the involvement of circRNAs in HCC diagnosis, prognosis, development, and drug resistance, suggesting that circRNAs may be a class of novel targets for improving HCC diagnosis, prognosis, and treatments. In fact, some artificial circRNAs have been engineered and showed their therapeutic potential in treating HCV infection and gastric cancer. In this review, we introduce the potential of circRNAs as biomarkers for HCC diagnosis and prognosis, as therapeutic targets for HCC treatments and discuss the challenges in circRNA research and chances of circRNA application.

引用

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