Case control;
Interval estimation;
Misclassification;
CONFIDENCE-INTERVALS;
PREVALENCE;
DISEASE;
ACCURACY;
D O I:
10.1080/03610910903312219
中图分类号:
O21 [概率论与数理统计];
C8 [统计学];
学科分类号:
020208 ;
070103 ;
0714 ;
摘要:
Positive predictive and negative predictive values (PPV and NPV) are often used to assess the accuracy of binary diagnostic tests. Unlike sensitivity and specificity, PPV and NPV are functions of the accuracy of the test and the overall prevalence of the disease in the population. In many studies of performance of estimators of PPV and NPV the population prevalence is assumed known. We allow for uncertainty in the estimate of the population prevalence and via simulation explore the impact of deviations from the assumed value.