Copper(I) Acetate: A Structurally Simple but Highly Efficient Dinuclear Catalyst for Copper-Catalyzed Azide-Alkyne Cycloaddition

被引：100

作者：

Shao, Changwei ^{[1
]}

Cheng, Guolin ^{[1
]}

Su, Deyong ^{[1
]}

Xu, Jimin ^{[1
]}

Wang, Xinyan ^{[1
]}

Hu, Yuefei ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 10期

关键词：

acetylides; catalysts; click chemistry; copper; cycloaddition; 1,3-DIPOLAR CYCLOADDITION; CRYSTAL-STRUCTURE; CLICK CHEMISTRY; HETEROGENEOUS CATALYST; TERMINAL ALKYNES; POLYMERS; LIGANDS; CYCLIZATION; DENDRIMERS; COMPLEX;

D O I：

10.1002/adsc.200900768

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this article, the structurally well-defined dinuclear complex copper(I) acetate was studied in detail and was developed as a highly practical and efficient catalyst for the copper(I)-catalyzed azide-alkyne cycloaddition. The "bare" phenylethynylcopper(I) (i.e., with no exogeneous ligands) was isolated as an intermediate, which can be converted into an active catalytic species by treatment with acetic acid (in situ produced in the reaction) to efficiently catalyze the azide-alkyne cycloaddition under mild conditions.

引用

页码：1587 / 1592

页数：6

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