Independent and joint effects of moderate alcohol consumption and smoking on the risks of non-alcoholic fatty liver disease in elderly Chinese men

被引：23

作者：

Liu, Peiyi ^{[1
,2
]}

Xu, Yanyan ^{[1
,2
]}

Tang, Yuhan ^{[1
,2
]}

Du, Min ^{[1
,2
]}

Yu, Xiao ^{[1
,2
]}

Sun, Jian ^{[1
,2
]}

Xiao, Lin ^{[1
,2
]}

He, Meian ^{[3
,4
]}

Wei, Sheng ^{[5
,6
]}

Yuan, Jing ^{[3
,4
]}

Wang, Youjie ^{[3
,4
]}

Liang, Yuan ^{[3
,4
]}

Wu, Tangchun ^{[3
,4
]}

Miao, Xiaoping ^{[5
,6
]}

Yao, Ping ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Nutr & Food Hyg, Hubei Key Lab Food Nutr & Safety, Wuhan, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE,Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China

[3] Huazhong Univ Sci & Technol, Inst Occupat Med, Wuhan, Hubei, Peoples R China

[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE,Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China

[5] Huazhong Univ Sci & Technol, Dept Epidemiol & Biostat, Wuhan, Hubei, Peoples R China

[6] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE,Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China

来源：

PLOS ONE | 2017年 / 12卷 / 07期

基金：

中国国家自然科学基金;

关键词：

ASIA-PACIFIC REGION; CIGARETTE-SMOKING; DECREASED PREVALENCE; METABOLIC SYNDROME; DIABETES-MELLITUS; POPULATION; STEATOHEPATITIS; ASSOCIATIONS; MANAGEMENT; FIBROSIS;

D O I：

10.1371/journal.pone.0181497

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background Whether cigarette smoking and moderate drinking are associated with non-alcoholic fatty liver disease (NAFLD) has not been fully described. This study investigated the separate and joint effects of smoking and moderate drinking on Chinese men with NAFLD. Methods Across-sectional assay from DFTJ Cohort study was performed with a size of 9432 elderly Chinese men excluding excessive alcohol consumption (<210g/week). Fatty liver was diagnosed by standardized ultrasonographic inspection. The odds ratio (OR) of alcohol consumption and smoking for the prevalence of NAFLD were analyzed using multiple logistic regression with multiple adjustments. Results The prevalence of NAFLD in current smokers (pack-year >= 40) and drinkers (80 similar to 210g/week or drinking duration >= 35years) was significantly higher than that in non-smokers and nondrinkers, respectively. The combination of current smoking (pack-year >= 40) and drinking (80 similar to 210g/week) was associated with the highest risk of NAFLD (OR 1.85; 95% confidence interval [CI] 1.28-2.68; P<0.01). The similar combined effect was found in participants with pack-year >= 40 and drinking duration >= 35 years (OR 1.72; 95% CI 1.26 -2.34; P<0.01). Moreover, an interaction was observed between current smoking and moderate drinking in NAFLD. Conclusions In elderly Chinese men, cigarette smoking and moderate alcohol consumption exerts an evident joint effect and interaction on the prevalence of NAFLD, although both are significantly and independently associated with NAFLD prevalence. Such findings highlight particular significance of avoidance of cigarette and alcohol on NAFLD prevention.

引用

页数：13