Three new sesquiterpene lactones from Carpesium abrotanoides

被引：8

作者：

Hu, Qiao-Ling ^{[1
]}

Wu, Pei-Qian ^{[1
]}

Liu, Ying-Hong ^{[1
]}

Qi, Feng-Ming ^{[2
]}

Yu, Chun-Xue ^{[1
]}

Zhao, Ye ^{[1
]}

Yu, Yi-Fan ^{[1
]}

Fei, Dong-Qing ^{[1
]}

Zhang, Zhan-Xin ^{[1
]}

机构：

[1] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2018年 / 27卷

基金：

中国国家自然科学基金;

关键词：

Asteraceae; Carpesium abrotanoides; Chemical constituents; Sesquiterpene lactone; Cytotoxic activities; CYTOTOXIC GERMACRANOLIDES; ESTERS; TRISTE; SEEDS;

D O I：

10.1016/j.phytol.2018.07.010

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new sesquiterpene lactones, 5 alpha-hydroxy-4 alpha,15-epoxy-11 alpha H-eudesman-12,8 beta-olide (1), carabrol-4-O-pal-mitate (2) and carabrol-4-O-linoleate (3), along with five known ones, were isolated from the whole plant of Carpesium abrotanoides. The structures of new compounds were determined by extensive spectroscopic analysis, and compound 1 was also elucidated by X-ray single-crystal diffraction analysis. The cytotoxic activities of these new compounds against human leukemia cells HL-60 and human breast cancer cells MCF-7 were also evaluated by MTS method.

引用

页码：154 / 159

页数：6

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