Chitosan-silica Sulfate Nano Hybrid: An Efficient Biopolymer Based-heterogeneous Nano Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidine-2 (1H) -one/thiones

被引：5

作者：

Behrouz, Somayeh ^{[1
]}

Abi, Masoome Nazar ^{[1
]}

Piltan, Mohammad Amin ^{[1
]}

机构：

[1] Shiraz Univ Technol, Dept Chem, Med Chem Res Lab, Shiraz 71555313, Iran

来源：

ACTA CHIMICA SLOVENICA | 2021年 / 68卷 / 02期

关键词：

Chitosan-silica sulfate nano hybrid; 3,4-Dihydropyrimidines; green chemistry; heterogeneous catalysis; multicomponent reaction; ONE-POT SYNTHESIS; HIGHLY EFFICIENT; 3-COMPONENT SYNTHESIS; BIGINELLI REACTION; GREEN SYNTHESIS; GRAPHENE OXIDE; SULFURIC-ACID; NANOCATALYST; DERIVATIVES; PROFICIENT;

D O I：

10.17344/acsi.2020.6343

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A green and highly efficient approach for the synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives is described. In this approach, the three-component Biginelli reaction between (thio)urea, methyl acetoacetate and aldehydes under solvent-free condition in the presence of chitosan-silica sulfate nano hybrid (CSSNH) as a green and heterogeneous nano catalyst affords the corresponding products in good to excellent yields and in short reaction times. CSSNH is a cheap, eco-friendly, and non-toxic nano catalyst that could be easily prepared, handled, and reused for many reaction runs without significant loss of its activity.

引用

页码：374 / 386

页数：13

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