Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

被引：38

作者：

Aglago, Elom K. ^{[1
]}

Murphy, Neil ^{[1
]}

Huybrechts, Inge ^{[1
]}

Nicolas, Genevieve ^{[1
]}

Casagrande, Corinne ^{[1
]}

Fedirko, Veronika ^{[2
]}

Weiderpass, Elisabete ^{[3
]}

Rothwell, Joseph A. ^{[4
,5
]}

Dahm, Christina C. ^{[6
]}

Olsen, Anja ^{[7
,8
]}

Tjonneland, Anne ^{[7
,9
]}

Kaaks, Rudolf ^{[10
]}

Katzke, Verena ^{[10
]}

Schulze, Matthias B. ^{[11
,12
]}

Masala, Giovanna ^{[13
]}

Agnoli, Claudia ^{[14
]}

Panico, Salvatore ^{[15
]}

Tumino, Rosario ^{[16
]}

Sacerdote, Carlotta ^{[17
]}

Bueno-de-Mesquita, Bas H. ^{[18
]}

Derksen, Jeroen W. G. ^{[19
]}

Skeie, Guri ^{[20
]}

Gram, Inger Torhild ^{[20
]}

Brustad, Magritt ^{[20
]}

Jakszyn, Paula ^{[21
,22
]}

Sanchez, Maria-Jose ^{[23
,24
,25
,26
]}

Amiano, Pilar ^{[26
,27
]}

Huerta, Jose Maria ^{[26
,28
]}

Ericson, Ulrika ^{[29
]}

Wennberg, Maria ^{[30
]}

Perez-Cornago, Aurora ^{[31
]}

Heath, Alicia K. ^{[32
]}

Jenab, Mazda ^{[1
]}

Chajes, Veronique ^{[1
]}

Gunter, Marc J. ^{[1
]}

机构：

[1] WHO, Int Agcy Res Canc IARC, Nutr & Metab Branch, Lyon, France

[2] Emory Univ, Winship Canc Inst, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

[3] WHO, Int Agcy Res Canc IARC, Off Director, Lyon, France

[4] Univ Paris Saclay, UVSQ, INSERM, CESP,Fac Med, Villejuif, France

[5] Gustave Roussy, Villejuif, France

[6] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark

[7] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[8] Univ Aarhus, Dept Publ Hlth, Aarhus, Denmark

[9] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[10] German Canc Res Ctr, Fdn Publ Law, Heidelberg, Germany

[11] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[12] Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany

[13] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[14] Fdn IRCCS Ist Nazl Tumori Milano, Epidemiol & Prevent Unit, Milan, Italy

[15] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[16] Prov Hlth Author ASP 7, Canc Registry & Histopathol Dept, Ragusa, Italy

[17] Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy

[18] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands

[19] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[20] Arctic Univ Norway, Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[21] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Programme, Unit Nutr & Canc, Barcelona, Spain

[22] Ramon Llull Univ, Blanquerna Sch Hlth Sci, Barcelona, Spain

[23] Escuela Andaluza Salud Publ EASP, Granada, Spain

[24] Inst Invest Biosanitaria ibs GRANADA, Granada, Spain

[25] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[26] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain

[27] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, Donostia San Sebastian, Spain

[28] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[29] Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden

[30] Umea Univ, Sect Sustainable Hlth, Dept Publ Hlth & Clin Med, Umea, Sweden

[31] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[32] Imperial Coll London, Sch Publ Hlth, London, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2021年 / 149卷 / 04期

基金：

瑞典研究理事会; 英国医学研究理事会;

关键词：

biomarker; colorectal cancer; dietary intake; fatty acids; 2; SIDES; ASSOCIATION; COLON; DISEASE; LIPIDS;

D O I：

10.1002/ijc.33615

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450 112 participants (6162 developed CRC, median follow-up = 15 years). In a nested case-control study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariable-adjusted hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed using Cox and conditional logistic regression, respectively. Dietary total SFA (highest vs lowest quintile, HRQ5vsQ1 = 0.80; 95%CI:0.69-0.92), myristic acid (HRQ5vsQ1 = 0.83, 95%CI:0.74-0.93) and palmitic acid (HRQ5vsQ1 = 0.81, 95%CI:0.70-0.93) were inversely associated with CRC risk. Plasma myristic acid was also inversely associated with colon cancer risk (highest vs lowest quartile, ORQ4vsQ1 = 0.51; 95%CI:0.32-0.83), whereas a borderline positive association was found for plasma stearic acid (ORQ4vsQ1 = 1.63; 95%CI:1.00-2.64). Dietary total MUFA was inversely associated with colon cancer (per 1-SD increment, HR1-SD = 0.92, 95%CI: 0.85-0.98), but not rectal cancer (HR1-SD = 1.04, 95%CI:0.95-1.15, P-heterogeneity = 0.027). Dietary iTFA, and particularly elaidic acid, was positively associated with rectal cancer (HR1-SD = 1.07, 95%CI:1.02-1.13). Our results suggest that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the aetiology of CRC. Both dietary and plasma myristic acid levels were inversely associated with colon cancer risk, which warrants further investigation.

引用

页码：865 / 882

页数：18

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