Sirtuins in mammals: insights into their biological function

被引：1421

作者：

Michan, Shaday ^{[1
]}

Sinclair, David ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Paul F Glenn Labs Biol Mech Aging, Boston, MA 02115 USA

来源：

BIOCHEMICAL JOURNAL | 2007年 / 404卷

关键词：

ADP-ribosyl transferase activity; caloric restriction; deacetylase activity; resveratrol; SIR2 (silent information regulator 2); sirtuin (SIRT1-7);

D O I：

10.1042/BJ20070140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sirtuins are a conserved family of proteins found in all domains of life. The first known sirtuin, Sir2 (silent information regulator 2) of Saccharomyces cerevisiae, from which the family derives its name, regulates ribosomal DNA recombination, gene silencing, DNA repair, chromosomal stability and longevity. Sir2 homologues also modulate lifespan in worms and flies, and may underlie the beneficial effects of caloric restriction, the only regimen that slows aging and extends lifespan of most classes of organism, including mammals. Sirtuins have gained considerable attention for their impact on mammalian physiology, since they may provide novel targets for treating diseases associated with aging and perhaps extend human lifespan. In this review we describe our current understanding of the biological function of the seven mammalian sirtuins, SIRT1-7, and we will also discuss their potential as mediators of caloric restriction and as pharmacological targets to delay and treat human age-related diseases.

引用

页码：1 / 13

页数：13

共 141 条

[1] Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2 [J].

Afshar, G ;

Murnane, JP .

GENE, 1999, 234 (01) :161-168

[2] Silent information regulator 2α, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes [J].

Alcendor, RR ;

Kirshenbaum, LA ;

Imai, S ;

Vatner, SF ;

Sadoshima, J .

CIRCULATION RESEARCH, 2004, 95 (10) :971-980

[3] Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae [J].

Anderson, RM ;

Bitterman, KJ ;

Wood, JG ;

Medvedik, O ;

Sinclair, DA .

NATURE, 2003, 423 (6936) :181-185

[4] Mitochondrial uncoupling proteins in the CNS: In support of function and survival [J].

Andrews, ZB ;

Diano, S ;

Horvath, TL .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (11) :829-840

[5] Resveratrol - A boon for treating Alzheimer's disease? [J].

Anekonda, Thimmappa S. .

BRAIN RESEARCH REVIEWS, 2006, 52 (02) :316-326

[6] MODIFIERS OF POSITION EFFECT ARE SHARED BETWEEN TELOMERIC AND SILENT MATING-TYPE LOCI IN SACCHAROMYCES-CEREVISIAE [J].

APARICIO, OM ;

BILLINGTON, BL ;

GOTTSCHLING, DE .

CELL, 1991, 66 (06) :1279-1287

[7] Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration [J].

Araki, T ;

Sasaki, Y ;

Milbrandt, J .

SCIENCE, 2004, 305 (5686) :1010-1013

[8] Altered sirtuin expression is associated with node-positive breast cancer [J].

Ashraf, N. ;

Zino, S. ;

MacIntyre, A. ;

Kingsmore, D. ;

Payne, A. P. ;

George, W. D. ;

Shiels, P. G. .

BRITISH JOURNAL OF CANCER, 2006, 95 (08) :1056-1061

[9] LIFE EXTENSION BY DIETARY RESTRICTION IN THE BOWL AND DOILY SPIDER, FRONTINELLA-PYRAMITELA [J].

AUSTAD, SN .

EXPERIMENTAL GERONTOLOGY, 1989, 24 (01) :83-92

[10] Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells [J].

Bäckesjö, CM ;

Li, Y ;

Lindgren, U ;

Haldosén, LA .

JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 (07) :993-1002

← 1 2 3 4 5 6 7 8 9 10 →