In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease

被引：2
作者：
Besnard, Stephane [1 ]
Decressac, Michael [2 ]
Denise, Pierre [1 ]
机构：
[1] Univ Caen, INSERM, CHRU Caen, F-14032 Caen, France
[2] Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, Poitiers, France
来源：
NEUROREPORT | 2010年 / 21卷 / 07期
关键词：
dopamine; electrophysiology; graft; multiunit recording; Parkinson's disease; substantia nigra; transplanted cells; NIGRAL COMPACTA NEURONS; RAT SUBSTANTIA-NIGRA; ELECTROPHYSIOLOGICAL PROPERTIES; DOPAMINERGIC-NEURONS; NIGROSTRIATAL PATHWAY; SUSPENSION GRAFTS; PARS RETICULATA; TRANSPLANTS; RECONSTRUCTION; IDENTIFICATION;
D O I：
10.1097/WNR.0b013e328337f4ca
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We recently showed that intranigral transplantation of embryonic neurons in a mouse model of Parkinson's disease led to anatomical and functional recovery of the nigrostriatal pathway. Here we report, in-vivo electrophysiological characteristics of these grafted neurons 2 months after transplantation. Extracellular activity was mapped within the transplant using microarray electrodes and exploration was done with antidromic and orthodromic striatal stimulation. Grafted neurons expressed spontaneous electrophysiological activity with dopaminergic-like characteristics, and antidromic and orthodromic responses suggest a functional recovery of the nigrostriatal loop. NeuroReport 21:485-489 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：485 / 489
页数：5
相关论文
共 25 条
  • [1] THE ACTIVITY OF PARS COMPACTA NEURONS OF THE MONKEY SUBSTANTIA NIGRA IS DEPRESSED BY APOMORPHINE
    AEBISCHER, P
    SCHULTZ, W
    [J]. NEUROSCIENCE LETTERS, 1984, 50 (1-3) : 25 - 29
  • [2] ELECTROPHYSIOLOGICAL PROPERTIES OF SINGLE UNITS IN DOPAMINE-RICH MESENCEPHALIC TRANSPLANTS IN RAT-BRAIN
    ARBUTHNOTT, G
    DUNNETT, S
    MACLEOD, N
    [J]. NEUROSCIENCE LETTERS, 1985, 57 (02) : 205 - 210
  • [3] Bjorklund A, 1992, Curr Opin Neurobiol, V2, P683, DOI 10.1016/0959-4388(92)90039-N
  • [4] Cell replacement therapies for central nervous system disorders
    Björklund, A
    Lindvall, O
    [J]. NATURE NEUROSCIENCE, 2000, 3 (06) : 537 - 544
  • [5] THE GABA AND SUBSTANCE-P INPUT TO DOPAMINERGIC-NEURONS IN THE SUBSTANTIA-NIGRA OF THE RAT
    BOLAM, JP
    SMITH, Y
    [J]. BRAIN RESEARCH, 1990, 529 (1-2) : 57 - 78
  • [6] ANTIDROMIC LATENCY VARIATIONS OF NIGRAL COMPACTA NEURONS
    COLLINGRIDGE, GL
    JAMES, TA
    MACLEOD, NK
    [J]. EXPERIENTIA, 1980, 36 (08): : 970 - 971
  • [7] Do silent dopaminergic neurons exist in rat substantia nigra in vivo?
    Dai, M
    Tepper, JM
    [J]. NEUROSCIENCE, 1998, 85 (04) : 1089 - 1099
  • [8] Parkinson's disease: Mechanisms and models
    Dauer, W
    Przedborski, S
    [J]. NEURON, 2003, 39 (06) : 889 - 909
  • [9] ELECTROPHYSIOLOGICAL CHARACTERISTICS OF CELLS WITHIN MESENCEPHALON SUSPENSION GRAFTS
    FISHER, LJ
    YOUNG, SJ
    TEPPER, JM
    GROVES, PM
    GAGE, FH
    [J]. NEUROSCIENCE, 1991, 40 (01) : 109 - 122
  • [10] Anatomical and functional reconstruction of the nigrostriatal pathway by intranigral transplants
    Gaillard, Afsaneh
    Decressac, Mickael
    Frappe, Isabelle
    Fernagut, Pierre Olivier
    Prestoz, Laetitia
    Besnard, Stephan
    Jaber, Mohamed
    [J]. NEUROBIOLOGY OF DISEASE, 2009, 35 (03) : 477 - 488
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