PD-L1 Expression in Lung Adenocarcinomas Correlates with KRAS Mutations and Th1/Cytotoxic T Lymphocyte Microenvironment

被引:0
|
作者
Huynh, Tiffany [1 ]
Morales-Oyarvide, Vicente [2 ]
Uruga, Hironori [1 ]
Bozkurtlar, Emine [1 ]
Gainor, Justin F. [3 ]
Hata, Aaron [3 ]
Mark, Eugene [1 ]
Lanuti, Michael [4 ]
Engelman, Jeffrey A. [5 ]
Mino-Kenudson, Mari [1 ]
机构
[1] Massachusetts Gen Hosp, Pathol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Boston, MA 02115 USA
[3] Massachusetts Gen Hosp, Canc Ctr, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Thorac Surg, Boston, MA 02114 USA
[5] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
关键词
Immunotherapy; Tumor biology; lung cancer;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
ORAL13.01
引用
收藏
页码:S198 / S198
页数:1
相关论文
共 50 条
  • [41] Integration of Spatial PD-L1 Expression with the Tumor Immune Microenvironment Outperforms Standard PD-L1 Scoring in Outcome Prediction of Urothelial Cancer Patients
    Weyerer, Veronika
    Strissel, Pamela L.
    Strick, Reiner
    Sikic, Danijel
    Geppert, Carol I.
    Bertz, Simone
    Lange, Fabienne
    Taubert, Helge
    Wach, Sven
    Breyer, Johannes
    Bolenz, Christian
    Erben, Philipp
    Schmitz-Draeger, Bernd J.
    Wullich, Bernd
    Hartmann, Arndt
    Eckstein, Markus
    CANCERS, 2021, 13 (10)
  • [42] Magnitude of PD-1, PD-L1 and T Lymphocyte Expression on Tissue from Castration-Resistant Prostate Adenocarcinoma: An Exploratory Analysis
    Massari, Francesco
    Ciccarese, Chiara
    Calio, Anna
    Munari, Enrico
    Cima, Luca
    Porcaro, Antonio Benito
    Novella, Giovanni
    Artibani, Walter
    Sava, Teodoro
    Eccher, Albino
    Ghimenton, Claudio
    Bertoldo, Francesco
    Scarpa, Aldo
    Sperandio, Nicola
    Porta, Camillo
    Bronte, Vincenzo
    Chilosi, Marco
    Bogina, Giuseppe
    Zamboni, Giuseppe
    Tortora, Giampaolo
    Samaratunga, Hemamali
    Martignoni, Guido
    Brunelli, Matteo
    TARGETED ONCOLOGY, 2016, 11 (03) : 345 - 351
  • [43] PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD-L1 IHC Assay Comparison Project
    Hirsch, Fred R.
    McElhinny, Abigail
    Stanforth, Dave
    Ranger-Moore, James
    Jansson, Malinka
    Kulangara, Karina
    Richardson, William
    Towne, Penny
    Hanks, Debra
    Vennapusa, Bharathi
    Mistry, Amita
    Kalamegham, Rasika
    Averbuch, Steve
    Novotny, James
    Rubin, Eric
    Emancipator, Kenneth
    McCaffery, Ian
    Williams, J. Andrew
    Walker, Jill
    Longshore, John
    Tsao, Ming Sound
    Kerr, Keith M.
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (02) : 208 - 222
  • [44] Spatial heterogeneity of PD-L1 expression and the risk for misclassification of PD-L1 immunohistochemistry in non-small cell lung cancer
    Dori, Shani Ben
    Aizic, Asaf
    Sabo, Edmond
    Hershkovitz, Dov
    LUNG CANCER, 2020, 147 : 91 - 98
  • [45] A Mesoporous Gold Sensor Unveils Phospho PD-L1 in Extracellular Vesicles as a Proxy for PD-L1 Expression in Lung Cancer Tissue
    Shanmugasundaram, Karthik B.
    Ahmed, Emtiaz
    Miao, Xinzhe
    Kulasinghe, Arutha
    Fletcher, James A.
    Monkman, James
    Mainwaring, Paul
    Masud, Mostafa Kamal
    Park, Hyeongyu
    Hossain, Md Shahriar A.
    Yamauchi, Yusuke
    Sina, Abu A. I.
    O'Byrne, Kenneth
    Wuethrich, Alain
    Trau, Matt
    ACS SENSORS, 2024, 9 (06): : 3009 - 3016
  • [46] Relationship of the lung microbiome with PD-L1 expression and immunotherapy response in lung cancer
    Hye Jin Jang
    Ji Yeon Choi
    Kangjoon Kim
    Seung Hyun Yong
    Yeon Wook Kim
    Song Yee Kim
    Eun Young Kim
    Ji Ye Jung
    Young Ae Kang
    Moo Suk Park
    Young Sam Kim
    Young-Jae Cho
    Sang Hoon Lee
    Respiratory Research, 22
  • [47] Expression of PD-L1 Is Associated with Inflammatory Microenvironment in Surgical Specimens of Non-Small Cell Lung Cancer
    Simundza, Ivan
    Krnic, Dragan
    Juricic, Josko
    Benzon, Benjamin
    Simundza, Rina
    Stanicic, Ivan Mario
    Capkun, Vesna
    Vukojevic, Katarina
    Durdov, Merica Glavina
    JOURNAL OF PERSONALIZED MEDICINE, 2021, 11 (08):
  • [48] PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer
    Stein, Alexander
    Simnica, Donjete
    Schultheiss, Christoph
    Scholz, Rebekka
    Tintelnot, Joseph
    Goekkurt, Eray
    von Wenserski, Lisa
    Willscher, Edith
    Paschold, Lisa
    Sauer, Markus
    Lorenzen, Sylvie
    Riera-Knorrenschild, Jorge
    Depenbusch, Reinhard
    Ettrich, Thomas J.
    Doerfel, Steffen
    Al-Batran, Salah-Eddin
    Karthaus, Meinolf
    Pelzer, Uwe
    Waberer, Lisa
    Hinke, Axel
    Bauer, Marcus
    Massa, Chiara
    Seliger, Barbara
    Wickenhauser, Claudia
    Bokemeyer, Carsten
    Hegewisch-Becker, Susanna
    Binder, Mascha
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 (07)
  • [49] PD-1/PD-L1 axis importance and tumor microenvironment immune cells
    Lotfinejad, Parisa
    Kazemi, Tohid
    Mokhtarzadeh, Ahad
    Shanehbandi, Dariush
    Niaragh, Farhad Jadidi
    Safaei, Sahar
    Asadi, Milad
    Baradaran, Behzad
    LIFE SCIENCES, 2020, 259
  • [50] Expression of Three Clones of PD-L1 in Lung Cancer: A Single-center Experience
    Park, Sang-Gon
    Lee, Hee Jeong
    Lee, Seul Bi
    Hong, Ran
    IN VIVO, 2023, 37 (01): : 233 - 241