In situ investigation of Fas/FasL expression in chronic hepatitis B infection and related liver diseases

被引：43

作者：

Luo, KX ^{[1
]}

Zhu, YF ^{[1
]}

Zhang, LX ^{[1
]}

He, HT ^{[1
]}

Wang, XS ^{[1
]}

Zhang, L ^{[1
]}

机构：

[1] 302 HOSP,BEIJING,PEOPLES R CHINA

来源：

JOURNAL OF VIRAL HEPATITIS | 1997年 / 4卷 / 05期

关键词：

apoptosis of hepatocyte; chronic hepatitis B; chronic liver disease; Fas/FasL;

D O I：

10.1046/j.1365-2893.1997.00053.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

To evaluate Fas/FasL expression in hepatitis B virus-related chronic liver disease, liver biopsies from 44 such cases were studied immunohistochemically. Fast was detected in the infiltrating lymphocytes and both Fast and Fas were found in the hepatocytes, The Fas and Fast-positive cells were mostly found at the advancing edges of interphase hepatitis, and Fas/FasL expression was closely correlated with the inflammatory activity. Unexpectedly, Fast was also expressed in liver cirrhotic nodules, particularly in those with hepatocellular carcinoma with or without inflammation. These results suggest that the factors which induce hepatocyte transformation might also trigger Fast expression and promote FasL/Fas-mediated apoptosis.

引用

页码：303 / 307

页数：5

共 11 条

[1] Upregulation of fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes [J].