Levels of mRNA for dopaminergic receptor D5 in circulating lymphocytes may be associated with subsequent response to interferon-β in patients with multiple sclerosis

被引：15

作者：

Cosentino, Marco ^{[1
]}

Zaffaroni, Mauro ^{[2
]}

Marino, Franca ^{[1
]}

机构：

[1] Univ Insubria, Ctr Res Med Pharmacol, I-21100 Varese, VA, Italy

[2] Hosp S Antonio Abate, Multiple Sclerosis Ctr, Gallarate, VA, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 277卷 / 1-2期

关键词：

Multiple sclerosis; Interferon beta; Lymphocytes; Dopaminergic receptors; beta(2)-Adrenoceptors; Tyrosine hydroxylase; BLOOD MONONUCLEAR-CELLS; ENDOGENOUS CATECHOLAMINES; MEDICAL PROGRESS; T-CELLS; ACTIVATION; MANAGEMENT; DISEASE;

D O I：

10.1016/j.jneuroim.2014.10.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferon (IFN)-beta is among the first-line therapies for multiple sclerosis (MS), however the clinical response varies among individuals, and early identification of responders and non-responders would be of critical importance. Here we show that before treatment circulating lymphocytes of MS patients who will respond to IFN-beta have higher mRNA levels for the D-1-like dopaminergic receptor (DR) D-5 in comparison to cells from those who will not respond. Lymphocyte DR D-5 is reduced in MS and IFN-beta restores their expression and responsiveness. DR D-5 mRNA levels in circulating lymphocytes might represent an early marker of response to IFN-beta in MS patients. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：193 / 196

页数：4

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