Objective: To evaluate the female sexual dysfunction in both type 1 and type 2 diabetes mellitus (DM).Methods: This cross-sectional study was carried out at Suez Canal University Hospitals from the start of February 2015 to the end of May 2016 among 189 married premenopausal women attending endocrinology and diabetology outpatient clinic for regular follow-up; 25 of whom refused to participate and 18 more were excluded due to incomplete data sets resulting in a final sample of 146 diabetic females. Ninety healthy women were recruited from the administrative staff at the hospital as a control group. Sexual dysfunction was assessed using female sexual function index (FSFI), a validated 19-item, self-administered, screening questionnaire comprising the six major sexual domains: desire, arousal, lubrication, orgasm, satisfaction and pain. Responses to each question were reported and scored on 0-5 scale with 0 representing no sexual activity and 5 suggestive of normal sexual activity.Results: Prevalence of sexual dysfunction was significantly higher in both type 1 and 2DM groups (44 and 25%, respectively) than in the control group (9%). FSFI mean total score was significantly lower in type 1DM (21.13.9) than type 2DM (26.4 +/- 4.2) and both were significantly lower than the control group (31.5 +/- 5.8). With regard to FSFI domains, mean values for desire, arousal, lubrication, orgasm, satisfaction and pain were significantly lower in both type 1 and type 2DM groups when compared with the controls.Conclusion: FSD is a significant health problem among premenopausal diabetic Egyptian women. Type 1DM women were more affected than type 2DM that in turn was more affected than healthy control females.